Results 221 to 230 of about 4,766,757 (295)

The ACCEPTance of automation: refining circulating tumor cells enumeration for improved metastatic colorectal cancer prognosis

Molecular Oncology, EarlyView.
This study highlights the potential of automated enumeration using the ACCEPT software to refine circulating tumor cell (CTC) detection in metastatic colorectal cancer (mCRC). The automated method demonstrates improved accuracy and reduced variability compared to the manual approach.
Michela De Meo, Marco Siringo, Alessandro Vici, Ann Zeuner, Orietta Gandini, Paola Gazzaniga, Chiara Nicolazzo   +6 more
wiley   +1 more source

Seeing things the same way: perspectives and lessons learned from research-design collaborations. [PDF]

J Am Med Inform Assoc
Mangal S, Berger L, Bruzzese JM, de la Cruz A, Lor M, Naqvi IA, Solis de Ovando E, Spiegel-Gotsch N, Stonbraker S, Arcia A.   +9 more
europepmc   +1 more source

The design, development, and evaluation of a differential pressure gauge directional wave monitor / by Kevin R. Bodge ; prepared for U.S. Army Corps of Engineers Coastal Engineering Research Center.

, 1982
Kevin R. Bodge
openalex   +2 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Development of a Mobile-Based Personal Health Record for Pediatric Attention-Deficit/Hyperactivity Disorder Management: Protocol for a Study Based on Action Research Design.

JMIR Res Protoc
Santoso DB, Kristanti MS, Nurputra DK, Sutomo R.   +3 more
europepmc   +1 more source

NIIEFA RESEARCH AND DESIGN IN THE FIELD OF INERTIAL FUSION USING RELATIVISTIC ELECTRON BEAMS AND LASER

, 1980
V. A. Burtsev
openalex   +2 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Research on a noise control device (2nd report, The fundamental design of the device)

, 1985
Keiichiro MIZUNO, Hisayoshi SEKIGUCHI, Kazuyoshi IIDA   +2 more
openalex   +2 more sources

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Feasibility and acceptability of the Promoting Pupils' Physical Literacy (3PL) intervention and its effectiveness research design: A study protocol. [PDF]

PLoS One
Amholt TT, Kurtzhals M, Melby PS, Stage A, Issartel J, O'Brien W, Belton S, Bølling M, Nielsen G, Bentsen P, Elsborg P.   +10 more
europepmc   +1 more source