Results 91 to 100 of about 69,132,749 (274)

Reproducible Effects of Sex and Acquisition Order on Multiple Global Signal Metrics: Implications for Functional Connectivity Studies of Phenotypic Individual Differences Using fMRI

Brain and Behavior
Purpose The identification of relationships between individual differences in functional connectivity (FC) and behavior has been the focus of considerable investigation.
Henry W. Chase, Danella M. Hafeman, Merage Ghane, Alexander Skeba, Tyler Brady, Haris A. Aslam, Richelle Stiffler, Lisa Bonar, Simona Graur, Genna Bebko, Michele Bertocci, Satish Iyengar, Mary L. Phillips   +12 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Dimensional thinking in psychiatry in the era of the Research Domain Criteria (RDoC) [PDF]

Irish Journal of Psychological Medicine, 2017
The biological mechanisms underlying psychiatric diagnoses are not well defined. Clinical diagnosis based on categorical systems exhibit high levels of heterogeneity and co-morbidity. The Research Domain Criteria (RDoC) attempts to reconceptualize psychiatric disorders into transdiagnostic functional dimensional constructs based on neurobiological ...
J R, Kelly, G, Clarke, J F, Cryan, T G, Dinan   +3 more
openaire   +2 more sources

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

The Impact of Translational Neuroscience on Revisiting Psychiatric Diagnosis: State of the Art and Conceptual Analysis

Balkan Medical Journal, 2017
This paper reviews translational research in psychiatry, focusing on those programs addressing the problem of the validity of psychiatric diagnoses. In medicine in general, and in psychiatry in particular, the term “translational” is used with different ...
Massimiliano Aragona
doaj   +1 more source

Pediatric disinhibited eating: Toward a research domain criteria framework [PDF]

International Journal of Eating Disorders, 2013
Children with disinhibited eating behaviors rarely meet full criteria for DSM-defined eating disorders. Further, there is overwhelming agreement that the current system of psychiatric diagnosis does not adequately address the symptoms and problems with which patients of all ages present.
Marian, Tanofsky-Kraff, Scott, Engel, Jack A, Yanovski, Daniel S, Pine, Eric E, Nelson   +4 more
openaire   +2 more sources

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Current concerns in psychiatric diagnostic process and the paradigm shift: Research domain criteria

Journal of Mental Health and Human Behaviour, 2015
There are many issues around the current approaches in diagnosing psychiatric illnesses. Most of the diagnoses are symptom-clusters and not etiology based. Although they are reliable constructs, their validity has always been debated.
Nilamadhab Kar
doaj   +1 more source

Examining the Clinical Utility of Research Domain Criteria in an Outpatient Sample [PDF]

, 2018
This study examined the clinical utility of the recently released National Institute of Mental Health's (NIMH) research domain criteria (RDoC) by replicating and extending earlier work by using a demographically novel sample.
Love, Patrick K.
core   +1 more source