Results 91 to 100 of about 2,205,527 (302)

Pediatric disinhibited eating: Toward a research domain criteria framework [PDF]

International Journal of Eating Disorders, 2013
Children with disinhibited eating behaviors rarely meet full criteria for DSM-defined eating disorders. Further, there is overwhelming agreement that the current system of psychiatric diagnosis does not adequately address the symptoms and problems with which patients of all ages present.
Marian, Tanofsky-Kraff, Scott, Engel, Jack A, Yanovski, Daniel S, Pine, Eric E, Nelson   +4 more
openaire   +2 more sources

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

The Importance of Sensory Processing in Mental Health: A Proposed Addition to the Research Domain Criteria (RDoC) and Suggestions for RDoC 2.0

Frontiers in Psychology, 2019
The time is ripe to integrate burgeoning evidence of the important role of sensory and motor functioning in mental health within the National Institute of Mental Health’s [NIMH] Research Domain Criteria [RDoC] framework (National Institute of Mental ...
Laura A. Harrison, Anastasiya Kats, Marian E. Williams, L. Aziz-Zadeh   +3 more
semanticscholar   +1 more source

The human connectome project for disordered emotional states: Protocol and rationale for a research domain criteria study of brain connectivity in young adult anxiety and depression

NeuroImage, 2020
Through the Human Connectome Project (HCP) our understanding of the functional connectome of the healthy brain has been dramatically accelerated. Given the pressing public health need, we must increase our understanding of how connectome dysfunctions ...
L. Tozzi, Brooke R. Staveland, Bailey Holt-Gosselin, M. Chesnut, Sarah E. Chang, David Choi, Melissa Shiner, Hua Wu, Garikoitz Lerma-Usabiaga, O. Sporns, D. Barch, I. Gotlib, T. Hastie, A. Kerr, R. Poldrack, B. Wandell, M. Wintermark, L. Williams   +17 more
semanticscholar   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Using the research domain criteria (RDoC) to conceptualize impulsivity and compulsivity in relation to addiction

, 2017
Nomenclature for mental disorder was updated in 2013 with the publication of the fifth edition of the Diagnostic and Statistical Manual (DSM-5). In DSM-5, substance use disorders are framed as more dimensional.
Dan J. Stein, Brooks, Samantha,, Samantha J. Brooks, Christine Lochner, Stein, Dan J.,, Lochner, Christine,, Steve Shoptaw, Shoptaw, Steve,   +7 more
core   +1 more source

Examining the Clinical Utility of Research Domain Criteria in an Outpatient Sample [PDF]

, 2018
This study examined the clinical utility of the recently released National Institute of Mental Health's (NIMH) research domain criteria (RDoC) by replicating and extending earlier work by using a demographically novel sample.
Love, Patrick K.
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

A scoping review on the extent and nature of anxiety-related research within the research domain criteria (RDoC) framework: Limited coverage using non-disorder-specific search terms

, 2021
The need for research on modifiable risk factors in anxiety has been highlighted in previous reviews synthesizing literature on the etiology and maintenance of anxiety.
Maryann Wei (7375637), Steven Roodenrys (3706108)   +1 more
core  

Understanding Suicide Risk Within the Research Domain Criteria (RDoC) Framework: Insights, Challenges, and Future Research Considerations [PDF]

, 2018
Suicide is a leading cause of death worldwide. Prior research has focused primarily on sociodemographic and psychiatric risk factors with little improvement in the prediction or prevention of suicidal behavior over time.
Nock, Matthew, Cha, Christine, Glenn, Catherine R., Kleiman, Evan   +3 more
core   +1 more source