Results 81 to 90 of about 2,205,527 (302)

Building an Advance Domain Ontology Model of Information Science (OIS)

, 2014
The paper describes the process of modelling domain knowledge of Information Science (IS) by creating an Ontology of Information Science domain (OIS).
Lu, Joan, Sawsaa, Ahlam F., Sawsaa, Ahlam, Lu, Zhongyu   +3 more
core   +1 more source

The Impact of Translational Neuroscience on Revisiting Psychiatric Diagnosis: State of the Art and Conceptual Analysis

Balkan Medical Journal, 2017
This paper reviews translational research in psychiatry, focusing on those programs addressing the problem of the validity of psychiatric diagnoses. In medicine in general, and in psychiatry in particular, the term “translational” is used with different ...
Massimiliano Aragona
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

How to transition to Research Domain Criteria for Social and Behavioral Science Research

, 2021
Qualitative researchers often rely upon the American Psychiatric Association’s Diagnostic and Statistical Manual (DSM) for the classification of mental disorders for their research. Many qualitative researchers have assumed that these classifications are
Mehl-Madrona, Lewis E., Mainguy, Barbara Jane   +1 more
core  

Transsemptomatic Diagnosis as a Replacement for Transdiagnostic Approach in Psychiatry

Psikiyatride Güncel Yaklaşımlar
Traditionally, the DSM and ICD diagnostic systems have been based on the principle that mental disorders are separate diseases with different etiologies and clinical manifestations.
Osman Özdemir
doaj   +1 more source

The biological classification of mental disorders (BeCOME) study: a protocol for an observational deep-phenotyping study for the identification of biological subtypes

BMC Psychiatry, 2020
Background A major research finding in the field of Biological Psychiatry is that symptom-based categories of mental disorders map poorly onto dysfunctions in brain circuits or neurobiological pathways.
Tanja M. Brückl, Victor I. Spoormaker, Philipp G. Sämann, Anna-Katharine Brem, Lara Henco, Darina Czamara, Immanuel Elbau, Norma C. Grandi, Lee Jollans, Anne Kühnel, Laura Leuchs, Dorothee Pöhlchen, Maximilian Schneider, Alina Tontsch, Martin E. Keck, Leonhard Schilbach, Michael Czisch, Susanne Lucae, Angelika Erhardt, Elisabeth B. Binder   +19 more
doaj   +1 more source

The associations of Positive and Negative Valence Systems, Cognitive Systems and Social Processes on disease severity in anxiety and depressive disorders

Frontiers in Psychiatry, 2023
BackgroundAnxiety and depressive disorders share common features of mood dysfunctions. This has stimulated interest in transdiagnostic dimensional research as proposed by the Research Domain Criteria (RDoC) approach by the National Institute of Mental ...
Bernd R. Förstner, Sarah Jane Böttger, Alexander Moldavski, Malek Bajbouj, Andrea Pfennig, André Manook, Marcus Ising, Andre Pittig, Andre Pittig, Ingmar Heinig, Andreas Heinz, Klaus Mathiak, Klaus Mathiak, Thomas G. Schulze, Thomas G. Schulze, Thomas G. Schulze, Frank Schneider, Frank Schneider, Inge Kamp-Becker, Andreas Meyer-Lindenberg, Frank Padberg, Tobias Banaschewski, Michael Bauer, Rainer Rupprecht, Hans-Ulrich Wittchen, Hans-Ulrich Wittchen, Michael A. Rapp, Mira Tschorn   +27 more
doaj   +1 more source

Dimensional thinking in psychiatry in the era of the Research Domain Criteria (RDoC) [PDF]

Irish Journal of Psychological Medicine, 2017
The biological mechanisms underlying psychiatric diagnoses are not well defined. Clinical diagnosis based on categorical systems exhibit high levels of heterogeneity and co-morbidity. The Research Domain Criteria (RDoC) attempts to reconceptualize psychiatric disorders into transdiagnostic functional dimensional constructs based on neurobiological ...
J R, Kelly, G, Clarke, J F, Cryan, T G, Dinan   +3 more
openaire   +2 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Research domain criteria from neuroconstructivism: a developmental view on mental disorders [PDF]

, 2018
Neuroconstructivism can provide Research Domain Criteria (RDoC) with a developmental framework to understand mental disorders. Neuroconstructivism proposes that mental disorders are the outcome of a developmental trajectory.
Campos García, Ruth, Nieto Vizcaíno, María del Carmen, Nuñez Bernardos, María   +2 more
core   +1 more source