Results 81 to 90 of about 69,132,749 (274)
BMC Psychiatry, 2020 Background A major research finding in the field of Biological Psychiatry is that symptom-based categories of mental disorders map poorly onto dysfunctions in brain circuits or neurobiological pathways.
Tanja M. Brückl +19 more
doaj +1 more source
How to transition to Research Domain Criteria for Social and Behavioral Science Research
, 2021 Qualitative researchers often rely upon the American Psychiatric Association’s Diagnostic and Statistical Manual (DSM) for the classification of mental disorders for their research. Many qualitative researchers have assumed that these classifications are
Mehl-Madrona, Lewis E. +1 more
core
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Introduction Hyperlipidemia is a major risk factor for atherosclerotic cardiovascular disease (ASCVD). Although statins are the cornerstone of lipid‐lowering therapy, their use may be limited in some patients by adverse effects. This study evaluated the possible impact of non‐drug treatment using double‐filtration plasmapheresis (DFPP) on CD14+
Yun Cheng +3 more
wiley +1 more source
On Comparing Planning Domain Models [PDF]
, 2011 Whereas research into the characteristics and properties of AI planning algorithms is overwhelming, a similar science of domain model comparison and analysis is underdeveloped. It has long been acknowledged that there can be a range of di erent encodings
Shoeeb, S +2 more
core +2 more sources
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Research Domain Criteria: toward future psychiatric nosologies
Dialogues in Clinical Neuroscience, 2014 The Research Domain Criteria (RDoC) project was initiated by the National Institute of Mental Health (NIMH) in early 2009 as the implementation of Goal 1.4 of its just-issued strategic plan. In keeping with the NIMH mission, to "transform the understanding and treatment of mental illnesses through basic and clinical research," RDoC was explicitly ...
openaire +4 more sources
The Research Domain Criteria (RDoC) and the historical roots of psychopathology: A viewpoint [PDF]
European Psychiatry, 2019 AbstractIn this article we aim at conceptual reconstruction of the historical background behind RDoC project. It incorporates some elements that have not heretofore been included in frameworks for psychopathology research. At the same time, however, RDoC – like any approach to mental illness – must grapple with longstanding challenges in addressing ...
Drozdstoy, Stoyanov +2 more
openaire +2 more sources
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Business Domain Modelling using an Integrated Framework [PDF]
, 2015 This paper presents an application of a “Systematic Soft Domain Driven Design Framework” as a soft systems approach to domain-driven design of information systems development.
Wade, Steve, Salahat, Mohammed
core +2 more sources