Results 121 to 130 of about 5,021,475 (359)
Ethics outside, within or beyond OR models [PDF]
Since ethical concerns are calling for more attention within Operational Research, we present three approaches to combine Operational Research models with ethics.
Luk N. Van Wassenhove, Marc Le Menestrel
core
Research Ethics and Fieldwork at New Consumption Communities [PDF]
, 2005 It is hard to deny that marketing practice has changed considerably during recent years. This is reflected in its increased focus on customisation, coproduction and interactive marketing, much of which has been enabled by new information technologies ...
Bekin, C
core
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
AGRO-ETHICS: EXTENSION, RESEARCH, AND TEACHING [PDF]
Teaching/Communication/Extension/Profession,
Johnson, Glenn L.
core +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Qualitative Research in Sport Sciences: Is the Biomedical Ethics Model Applicable?
Forum: Qualitative Social Research, 2003 Research in sports science has historically been grounded in positivist traditions. This means that ethics committees may not be adequately sensitized to the ethical problems posed by qualitative research.
Steve Olivier, Lesley Fishwick
doaj
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
LinguisticsWhat aspects of a linguist’s work should be covered in training for ethical linguistics? Are they specific to the study of language? Specific to the treatment of research subjects? Specific to the practice of research?
Dobrin Lise M.
doaj +1 more source