Results 121 to 130 of about 5,045,747 (304)
Radical research as research at the roots: Practitioner self-image, public relations and ethics [PDF]
, 2008 Semantically, radical derives from ‘radix’, the Latin for root. This paper argues that little public relations research goes back to the roots of actual practice and addresses this neglect through a project focusing on practitioner accounts of their work.
Toledano, Margalit
core +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Qualitative Research in Sport Sciences: Is the Biomedical Ethics Model Applicable?
Forum: Qualitative Social Research, 2003 Research in sports science has historically been grounded in positivist traditions. This means that ethics committees may not be adequately sensitized to the ethical problems posed by qualitative research.
Steve Olivier, Lesley Fishwick
doaj
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
BMC Public HealthBackground Informing the public about lifestyle-related risk factors for colorectal cancer (CRC) is central for cancer prevention. More knowledge is needed about the public’s perceptions of CRC risk and how it relates to their lifestyle decisions, in ...
Erica Sundell +4 more
doaj +1 more source
Guest Editorial ... Ethical Issues in Community and Research Medicine [PDF]
, 1971 The following guest editorial by Saltonstall Professor of Population Ethics, Arthur J. Dyck, is reprinted from the New England Journal of Medicine. In it reference is made to an article, Ethics of a Cottage Industry in an Age of Community and Research ...
Dyck, Arthur J.
core +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source