Results 111 to 120 of about 5,085,695 (304)

Guest Editorial ... Ethical Issues in Community and Research Medicine [PDF]

open access: yes, 1971
The following guest editorial by Saltonstall Professor of Population Ethics, Arthur J. Dyck, is reprinted from the New England Journal of Medicine. In it reference is made to an article, Ethics of a Cottage Industry in an Age of Community and Research ...
Dyck, Arthur J.
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Ethics outside, within or beyond OR models [PDF]

open access: yes
Since ethical concerns are calling for more attention within Operational Research, we present three approaches to combine Operational Research models with ethics.
Luk N. Van Wassenhove, Marc Le Menestrel
core  

Concept, Principles and Research Methods of African Environmental Ethics [PDF]

open access: yes, 2018
[English] This paper aims to discuss ten traditional and contemporary methodological paradigms in African philosophy, and demonstrates how they may apply to African environmental ethics research.
Ibanga, Diana-Abasi
core  

RIPK4 function interferes with melanoma cell adhesion and metastasis

open access: yesMolecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski   +9 more
wiley   +1 more source

AGRO-ETHICS: EXTENSION, RESEARCH, AND TEACHING [PDF]

open access: yes
Teaching/Communication/Extension/Profession,
Johnson, Glenn L.
core   +1 more source

Radical research as research at the roots: Practitioner self-image, public relations and ethics [PDF]

open access: yes, 2008
Semantically, radical derives from ‘radix’, the Latin for root. This paper argues that little public relations research goes back to the roots of actual practice and addresses this neglect through a project focusing on practitioner accounts of their work.
Toledano, Margalit
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

Codes of Ethics in Research and Experimentation in Man [PDF]

open access: yes, 1973
Professor Liley\u27s most notable contribution to medicine was the introduction of intrauterine fetal blood transfusion in the management of Rh sensitization. His work has had worldwide recognition.
Liley, A. W.
core   +1 more source

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