Results 111 to 120 of about 69,241,719 (300)

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

MANUAL FOR RESEARCH ETHICS COMMITTEES

open access: yes, 2003
Editorial board -- Acknowledgements -- List of contributors - - Introduction / Sue Eckstein -- Pt. 1. Section I. Fundamental ethical and legal considerations -- Ch. 1. The ethics of clinical research / Calliope (Bobbie) Farsides -- Ch. 2.
Eckstein, Sue, ed.   +1 more
core  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

දිවි තොරකර ගැනීම් සහ දෝෂාරෝපණයන්: ආචාර ධාර්මික මාධ්‍යකරණයද?

open access: yes, 2021
On March 01,2021 Sunday Observer reported on suicide in a manner that did not comply with media ethics ...
Ethics Eye
core  

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

ප්‍රේමයෙන් මුසපත් වී බෑගයෙන් සහ කඹයෙන් අවසන් ගමනේ

open access: yes, 2021
On March 07 Divaina reported on suicide and Murder in a manner that did not comply with media ethics ...
Ethics Eye
core  

Colorectal cancer risk: stereotypical assumptions and competing values – a qualitative study with the general public

open access: yesBMC Public Health
Background Informing the public about lifestyle-related risk factors for colorectal cancer (CRC) is central for cancer prevention. More knowledge is needed about the public’s perceptions of CRC risk and how it relates to their lifestyle decisions, in ...
Erica Sundell   +4 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

දිවි අහිමිකරගනීම පිළිබඳ පුවත් වාර්තාකරණය: සිද්ධිය සරල කිරීම සහ සියදිවි නසා ගැනීමේ ක්‍රමය අනාවරණය කිරීම

open access: yes, 2020
This entry includes 11 write-ups and 11 infographics (all in Sinhala)In October 2020, Sinhala press including Aruna, Mawbima, Dinamina, Divaina, Lankadeepa and Ada reported on suicide violating certain media ethics.
Ethics Eye
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

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