Results 91 to 100 of about 5,085,695 (304)
Ethics and governance in social work research in the UK [PDF]
, 2006 The application of formal research ethics and governance structures in social work research have lagged behind those applicable in health, although in the UK, social care has been deemed to be covered by those that were used in the NHS.
Dominelli, Lena, Holloway, Margaret
core +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
A Malawi guideline for research study participant remuneration [version 2; referees: 2 approved]
Wellcome Open Research, 2018 Background: Research participant remuneration has been variable and inconsistent world-wide for many years owing to uncertainty regarding best practice and a lack of written guidelines for investigators and research ethics committees.
Stephen B. Gordon +6 more
doaj +1 more source
International Research Ethics Education [PDF]
, 2015 This paper assesses the state of research ethics in low- and middle-income countries and the achievements of the Fogarty International Center's bioethics training program since 2000.
Glass, R., Millum, J., Sina, B.
core +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
BioéthiqueOnline, 2013 This letter proposes a clarification regarding the use of the TCPS2 for ethics review in response to the exemption from review of a specific research proposal by the research ethics board of the organisation.
Caillé, Jean, Beauregard, Guy
doaj
BMC Medical EthicsBackground Therapeutic misconception (TM) among research participants refers to the conflation of research goals (generating generalisable knowledge) with clinical care goals (making the best decisions for the participants).
Thibaud Haaser +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Un projet de recherche exempté d’évaluation éthique : quelques précisions
BioéthiqueOnline, 2013 This piece responds to the comments made by Caillé and Beauregard by offering clarifications regarding the exemption from ethics review of a research project.
Durand, Céline, Fortin, Marie-Chantal
doaj
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source