Results 121 to 130 of about 69,241,719 (300)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

දිවි තොර කරගනු ලබන ප්‍රදේශ ප්‍රචලිත නොකරමු

, 2021
On March 04,2021 Aruna reported on suicide in a manner that did not comply with media ethics ...
Ethics Eye
core  

Qualitative Research in Sport Sciences: Is the Biomedical Ethics Model Applicable?

Forum: Qualitative Social Research, 2003
Research in sports science has historically been grounded in positivist traditions. This means that ethics committees may not be adequately sensitized to the ethical problems posed by qualitative research.
Steve Olivier, Lesley Fishwick
doaj  

Assessing satisfaction and performance of the CUREC electronic submission system

BMC Medical Ethics
Background In Thailand, online electronic submission systems play an essential role in facilitating research review. Developing a system that addresses the diverse needs of all stakeholders remains a major challenge for the research committee. This study
Waraya Krisnoi, Issaree Khemakanaka, Peeraphon Lueboonthavatchai, Prida Tasanapradit, Raveenan Mingpakanee, Nuntaree Chaichanawongsaroj   +5 more
doaj   +1 more source

Narrative Inquiry as a nursing research methodology: reflection on ethical considerations

Onco.News
Introduction: There is an emerging propensity to use narrative inquiry as a nursing research methodology. The narrative inquiry aims to understand experiences and reveal the meaning of individual experiences providing crucial knowledge. The relationship
Inês Frade, Vanda Marques Pinto, Luisa D'Espiney   +2 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

ප්‍රේමයෙන් මුසපත් වී බෑගයෙන් සහ කඹයෙන් අවසන් ගමනේ: දිවි තොර කරගත් ආකාරය ඡායාරුපයකින් දක්වන දිවයින

, 2021
On March 07,2021 Divaina reported on suicide murder in a manner that did not comply with media ethics ...
Ethics Eye
core  

Research ethics: ethical review and beyond

Science is a collective endeavor highly dependent on public acceptance and trust. Research findings must be reliable to serve the surrounding society as well as the research community itself. Evidence-based practice and policy recommendations may become ineffective or even dangerous if based on fraudulent research findings.
Elin Palm, Lars Lindblom
openaire   +2 more sources

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source