Results 161 to 170 of about 5,085,695 (304)

The Impact of "Ethics Creep" on Research, Teaching and Learning in the Social Sciences and Humanities: A Survey of Canadian Researchers' Experience with Research Ethics Boards. [PDF]

Can Rev Sociol
Gallagher-Mackay K, Robson KL, Pulchny A.   +2 more
europepmc   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Research ethics and integrity challenges in accelerated clinical trials, an interview study. [PDF]

BMC Med Ethics
Pallisé Perelló C, Inguaggiato G, van Eck L, de Jong HK, Hermans SM, Grobusch MP, van den Hoven M, Evans N.   +7 more
europepmc   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Convergences and Gaps between Environmental Ethics, Climate Ethics, and Research Ethics: A Scoping Review. [PDF]

Sci Eng Ethics
Bourban M, Lenzi D, Sørensen MP, Fishberg R, Mehlich J, Fischbach F, Molina JL, Poague KIHM, Csábi A, Heffernan R, Hastings R, Rességuier A.   +11 more
europepmc   +1 more source

Research Ethics and Research Governance [PDF]

Journal of Empirical Research on Human Research Ethics, 2012
Joan E, Sieber, Martin, Tolich
openaire   +2 more sources

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

"Who are you going to call?:" Research ethics consultation directors' perspectives on barriers and facilitators. [PDF]

J Clin Transl Sci
Miner SA, McCormick JB, Taylor HA.
europepmc   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source