Results 191 to 200 of about 5,021,475 (359)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Evaluation of the first standardized registry of approved research studies by the research ethics committees in Ecuador. [PDF]

BMC Med Ethics
Simbaña-Rivera K, Jaramillo-Aguilar DS, Arteaga VHA, Estupiñán JR.   +3 more
europepmc   +1 more source

Ethics, collective health, qualitative health research and social justice [PDF]

, 2015
Iara Coelho Zito Guerriero, Fernando Peñaranda Correa   +1 more
openalex   +1 more source

Research ethics - revisited [PDF]

Scandinavian Journal of Primary Health Care, 2003
openaire   +2 more sources

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

A Scoping Review of Empirical Research on Research Ethics Board Membership and Expertise. [PDF]

J Empir Res Hum Res Ethics
Tumilty E, Young J, James R, Serpico K, Johnson A, Anderson EE.   +5 more
europepmc   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

The role of research ethics committees in addressing optimism in sample size calculations: a meta-epidemiological study. [PDF]

Res Integr Peer Rev
Jansen MS, Groenwold RHH, Dekkers OM.
europepmc   +1 more source

Guidande note: ethics and food-related research [PDF]

, 2012
Alfonsi, Alfonso, Coles, David, Hasle, Christine, Koppel, Juraj, Ladikas, Miltos, Schmucker von Koch, Joseph, Schroeder, Doris, Sprumont, Dominique, Verbeke, Wim, Zaruk, David   +9 more
core  

Statistics and ethics in medical research. [PDF]

, 1981
M R Clarke
openalex   +1 more source