Results 61 to 70 of about 3,895,024 (310)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

The Place of the Issue in the Effectiveness of Historical Research [PDF]

open access: yesپژوهش‌نامۀ انتقادی متون و برنامه‌های علوم انسانی, 2018
As the concern and ambiguity that a historian has extracted from the subject under study and attempts to explain and interpret it, this issue can be articulated in two ways: one aspect of the issue that is strongly intertwined with the subject and past ...
Seyed Abolfazl Razavi
doaj  

“Playground of the People”? Mapping Racial Covenants in Twentieth-century Minneapolis

open access: yesOpen Rivers, 2017
The Mapping Prejudice project has brought veteran property researcher Penny Petersen together with scholars and students from Augsburg College and the University of Minnesota to unearth and map racially restrictive property deeds in Minneapolis.
Kirsten Delegard and Kevin Ehrman-Solberg
doaj   +1 more source

WS04: Haemophilia: Recent History of Clinical Management (10-Feb1998)

open access: yes, 2017
Selection of photos taken at the Witness Seminar “Haemophilia: Recent History of Clinical Management” held by the History of Twentieth Century Medicine Group, 10-Feb-1998.

core  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

River Conservancy and the Undetermined Future of the Port of Tianjin, 1888-1937

open access: yesOpen Rivers, 2017
Across the last several decades of China’s last imperial dynasty, the Qing (1644-1912), and China’s first republic (1912-1949), on the banks of a river connecting Tianjin with the sea, the most important seaport of North China in the early twentieth ...
Kan Li
doaj   +1 more source

On the Fieldwork in Oral History Research

open access: yesWrocławski Rocznik Historii Mówionej, 2016
The article concerns the problem of a lack of both academic tools as well as a catalogue of basic epistemological objectives that could serve oral history in Poland.
Marta Kurkowska-Budzan
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

WS41: History of the National Survey of Sexual Attitudes and Lifestyles (14-Dec-2009)

open access: yes, 2017
Selection of photos taken at the Witness Seminar “History of the National Survey of Sexual Attitudes and Lifestyles” held by the History of Modern Biomedicine Research Group,14-Dec-2009.

core  

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

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