Results 111 to 120 of about 30,282,823 (310)

Biallelic Inactivation of NSD1 Associated With Carcinogenesis in Sotos Syndrome

Pediatric Blood &Cancer, EarlyView.
Nicholas A. Borja, Anuja Sule, Katie Ann McMullen, Aditi Dhir, Matthew D. Hall, Heather J. McCrea, Sakir Humayun Gultekin, Mustafa Tekin, Bradley Gampel   +8 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Jitegemee (rely on yourself): a cross-sectional study on acceptability, feasibility and design considerations for a personal savings intervention to reduce HIV risk among female sex workers in Siaya County, Kenya

BMJ Open
Objectives The primary objective was to assess the acceptability of a savings intervention in which female sex workers (FSW) would save part of their earnings and call back (withdraw) when faced with a financial need that could force them into HIV risk ...
Harsha Thirumurthy, Kawango Agot, Nicky Okeyo, Jacob Onyango, Marylyn Ochillo, Gift-Noelle Wango, Moraa Arasa, Timothy Okello, Olivia Okumu, Shantana Carol, Bernard Ayieko   +10 more
doaj   +1 more source

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Exploring techno-economic landscapes of abatement options for hard-to-electrify sectors

Nature Communications
Approximately 20% of global CO2 emissions originate from sectors often labeled as hard-to-abate, which are challenging or impossible to electrify. Alternative abatement options are necessary for these sectors but face critical bottlenecks, particularly ...
Clara Bachorz, Philipp C. Verpoort, Gunnar Luderer, Falko Ueckerdt   +3 more
doaj   +1 more source

Designing impactful research [PDF]

, 2018
This chapter discusses the five key research design principles central to the applied scientific method which high quality research is recommended to adopt. These five principles are: (1) The inclusion of reliable and valid measures; (2) the inclusion of sufficient and generalizable research samples; (3) the inclusion of evidence of theoretical ...
Brough, Paula, Hawkes, Amy
openaire   +1 more source

The effects of the research excellence framework research impact agenda on early- and mid-career researchers in library and information science

Journal of information science, 2018
Early- and mid-career researchers will shape the future of library and information science (LIS) research and it is crucial they be well placed to engage with the research impact agenda. Their understanding of research impact may influence their capacity
R. Marcella, H. Lockerbie, Lyndsay Bloice, Caroline Hood, F. Barton   +4 more
semanticscholar   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Learning from the UK’s research impact assessment exercise: a case study of a retrospective impact assessment exercise and questions for the future

, 2017
National governments spend significant amounts of money supporting public research. However, in an era where the international economic climate has led to budget cuts, policymakers increasingly are looking to justify the returns from public investments ...
Molly Morgan Jones, Catriona Manville, J. Chataway   +2 more
semanticscholar   +1 more source