Results 111 to 120 of about 6,818,964 (313)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Interdisciplinary Research and Impact [PDF]

Global Challenges, 2019
Brown, Rebekah, Werbeloff, Lara, Raven, Rob   +2 more
openaire   +3 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Neural topic modeling reveals German television’s climate change coverage

Communications Earth & Environment
The implementation and acceptance of climate policies depend on public perceptions of climate change. The media play a crucial role in informing the public discourse.
Tatjana Schirmag, Jakob H. Wedemeyer, Annika Stechemesser, Leonie Wenz   +3 more
doaj   +1 more source

PolyU Research Impact – Smart Clinical Device for Kidney Disease Management

In English, with English and Chinese subtitles202410 bcwhVersion of RecordPublished109365Copyright retained by ...
YING, Tin Cheung Michael
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Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Exploring techno-economic landscapes of abatement options for hard-to-electrify sectors

Nature Communications
Approximately 20% of global CO2 emissions originate from sectors often labeled as hard-to-abate, which are challenging or impossible to electrify. Alternative abatement options are necessary for these sectors but face critical bottlenecks, particularly ...
Clara Bachorz, Philipp C. Verpoort, Gunnar Luderer, Falko Ueckerdt   +3 more
doaj   +1 more source

Jitegemee (rely on yourself): a cross-sectional study on acceptability, feasibility and design considerations for a personal savings intervention to reduce HIV risk among female sex workers in Siaya County, Kenya

BMJ Open
Objectives The primary objective was to assess the acceptability of a savings intervention in which female sex workers (FSW) would save part of their earnings and call back (withdraw) when faced with a financial need that could force them into HIV risk ...
Harsha Thirumurthy, Kawango Agot, Nicky Okeyo, Jacob Onyango, Marylyn Ochillo, Gift-Noelle Wango, Moraa Arasa, Timothy Okello, Olivia Okumu, Shantana Carol, Bernard Ayieko   +10 more
doaj   +1 more source

PolyU Research Impact – Envision Marine Conservation and Seafood Sustainability

In English, with English and Chinese subtitles202410 bcwhVersion of RecordPublished109366Copyright retained by ...
FANG, Kar-hei, James
core  

CGIAR GENDER Impact Platform Newsletter, April-May 2022, issue 1

, 2023
In this issue, we share with you latest news from the CGIAR GENDER Impact Platform as well as updates on gender research from across CGIAR's research portfolio.
CGIAR GENDER Impact Platform
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