Results 111 to 120 of about 4,864,275 (219)

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

How to … Maximise Your Clinical Education Research Impact. [PDF]

Clin Teach
Sims DA, Sandars J, Wong WYA, Samuriwo R, Burford B.   +4 more
europepmc   +1 more source

Reframing research impact. [PDF]

Patterns (N Y), 2022
Nelson APK.
europepmc   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

The National Health and Medical Research Council Research Impact Indicators: Unveiling Omissions and Blind Spots, and Positioning for Change. [PDF]

Health Promot J Austr
Abdu N, Unwin M, Robertson C, Black Anaiwan O, Palmer VJ, Wheeler AJ, Neil AL.   +6 more
europepmc   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

Using Social Media to Maximize the Research Impact of Surgeons: Exploratory Linguistic Analysis. [PDF]

JMIR Form Res
Berding S, Green E, Rynarzewska AI, Robinson SS, Royall NA, Jackson T.   +5 more
europepmc   +1 more source

Prioritising and incentivising productivity within indicator-based approaches to Research Impact Assessment: a commentary. [PDF]

Health Res Policy Syst, 2023
Deeming S, Hure A, Attia J, Nilsson M, Searles A.   +4 more
europepmc   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

C-PRISM: Complexity-informed profile for research impact and scholarly merit. [PDF]

J Family Med Prim Care
Raina SK, Kumar R, Kaushal K.
europepmc   +1 more source