Results 41 to 50 of about 1,087,779 (267)

The Changing Shape of Architecture: Further Cases of Integrating Research and Design in Practice

, 2019
The discipline of architecture if currently undergoing a significant change as professional practice and academia seem to be transforming one another specifically through succinct research undertakings.
Nilsson, Fredrik,, Hensel, Michael U., Nilsson, Fredrik, Hensel, Michael, Hensel, Michael U.,   +4 more
core   +1 more source

Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila

FEBS Letters, EarlyView.
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia, Anna Dósa, Asha Kiran Maddali, András Jipa, Hajnalka Laczkó‐Dobos, Péter Lőw, Gábor Juhász   +6 more
wiley   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Urban digital media: facilitating the intersection between science, the arts and culture in the arena of technology and building [PDF]

, 2010
The research presented in this paper investigates ways of providing better design applications for technologies in the field of Urban Digital Media (UDM).
Haeusler, M, Barker, Tom, T. Barker, H. Haeusler, Barker, T, Haeusler, Hank   +5 more
core  

Forgotten Architecture. An archive of less known modern architecture all over the world

, 2022
Conference held at NABA Milan, 26 May 2022. Forgotten Architecture was born on 28 May 2019 for sharing, in an online community, projects left in the shadows in Europe and the rest of the world.
Felicori, Bianca, Forgotten Architecture. An archive of less known modern architecture all over the world   +1 more
core  

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Developing Research Cultures in Architecture

, 2019
This chapter portrays an approach and particular case of developing research culture in architecture across practice, research organization, and education that commenced in the mid-1990s in the context of the OCEAN, an interdisciplinary network that ...
Hensel, Michael
core  

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Design practice research in architecture and design at RMIT University: Discovery, reflection and assessment

, 2017
This chapter explores the RMIT University approach to practice-based design research at doctoral level and in particular the assessment component of the PhD candidates and their practice-embedded research.
Adriana Partal, Partal, A., Fudge, Colin Edward,, Partal, A.,, Fudge, Colin Edward, Colin Fudge   +5 more
core   +1 more source