CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He +8 more
wiley +1 more source
HBM Package Interconnection Pseudo All-Channel Signal Integrity Simulation and Implementation Method of the Synchronous Current Load Research [PDF]
Wenfei Tang +8 more
openalex +1 more source
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Peer Review Week 2022: an interview with Rafal Marszalek, Si Ming Man and Guideng Li about their views on research integrity as scientists and editors [PDF]
openalex +1 more source
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Exam Security and Technology Governance Questionnaire (ESTG-Q): A Modular Instrument with an Item-Level Attitude-Marking Mechanism for Exam Integrity Research [PDF]
Dengfeng Hui +6 more
openalex +1 more source
The integrity and collaborative mode and path innovation research of College students' ideological and political education [PDF]
Xiaofei Wang
openalex +1 more source
Academic Integrity Among Engineering Undergraduates: Seven Years Of Research By The E^3 Team [PDF]
Cynthia Finelli +3 more
openalex +1 more source

