Results 231 to 240 of about 1,570,252 (311)

Fluorescent Nanosensor for Indole‐3‐Propionic Acid Detection in Gut Health Monitoring

Advanced Healthcare Materials, EarlyView.
This work introduces a fluorescent nanosensor system with two optical modalities for detection of indole‐3‐propionic acid (IPA) gut metabolite: (1) blue‐emitting cationic conjugated polyelectrolyte (CP3) and (2) near‐infrared (NIR)‐emitting CP3‐wrapped single‐walled carbon nanotube (SWNT).
Mervin Chun‐Yi Ang, Jonathan Wei Jie Lee, Sayyid Mohaideen, Gabriel Sánchez‐Velázquez, Song Wang, Yangyang Han, Liu Lin, Germaine Yong, Raju Cheerlavancha, Duc Thinh Khong, Jianhong Ching, Sharon Hong Yu Han, Jun Yu Yeo, Lian Xu, Gajendra Pratap Singh, Michael S. Strano   +15 more
wiley   +1 more source

Deep-mutational scanning libraries using Tiled-Region Exchange mutagenesis. [PDF]

G3 (Bethesda)
Kindree K, Chochinov CA, Bhachu K, Cheng Y, Caron A, McDonald M, Mamai Z, Nguyen Ba AN.   +7 more
europepmc   +1 more source

Infusible Extracellular Matrix Biomaterial Enhances Cell‐Specific Pro‐Repair Responses Following Acute Myocardial Infarction

Advanced Healthcare Materials, EarlyView.
We measure the cell‐specific responses of administering infusible ECM (iECM) in acute myocardial infarction (MI) across multiple timepoints. Using single‐nucleus RNA sequencing and spatial transcriptomics, we measure macrophage activation, fibroblast remodeling, increased vascular development, lymphangiogenesis, cardioprotection, and neurogenesis ...
Joshua M. Mesfin, Alexander Chen, Quincy P. Lyons, Michael B. Nguyen, Maria L. Karkanitsa, Justin Yu, Van K. Ninh, Emily Gardner, Elyse G. Wong, Sriya N. Paleti, Julian Cheng, Benjamin D. Bridgelal, Kate E. Reimold, Selena Cao, Connor Uhre, Colin G. Luo, Zhenxing Fu, Kevin R. King, Karen L. Christman   +18 more
wiley   +1 more source

Variation in guide RNA library representation results in gene effect score bias in genome-wide CRISPR screens. [PDF]

BMC Genomics
Metz P, Alves-Vasconcelos S, Wallbank R, Riepsaame J, Brown S, Hassan AB.   +5 more
europepmc   +1 more source

The Floor‐Ceiling‐Chip, or 2 × 2D = Pseudo‐3D—Approaching 3D Cell Morphology and Organization between Two Opposing 2D Substrates with Cell‐Adhesive Protein Micropatterns

Advanced Healthcare Materials, EarlyView.
Here, we present a novel 3D cell patterning and culture platform. The “Floor‐Ceiling‐Chip” (FC‐Chip) consists of two opposing track‐etched membranes, creating a pseudo‐3D microenvironment for the cells in between. By providing the membranes with micropatterned cell‐adhesive islands of varying geometries and sizes, the FC‐Chip enables control over cell ...
Urandelger Tuvshindorj, Francesca Giacomini, Esra Güben Kaçmaz, Tim ten Brink, Lorenzo Moroni, Zeinab Tahmasebi Birgani, Clemens van Blitterswijk, Pamela Habibović, Stefan Giselbrecht, Jan de Boer, Roman Truckenmüller   +10 more
wiley   +1 more source

Comprehensive Curation and Harmonization of Small-Molecule MS/MS Libraries in Spectraverse. [PDF]

Anal Chem
Gupta V, Qiang H, Chung HH, Herbst E, Skinnider MA.   +4 more
europepmc   +1 more source

Chamber‐Specific Decellularized Extracellular Matrices Differentially Modulate Cardiomyocyte Subtypes to Drive Engineered Heart Tissue Development and Function

Advanced Healthcare Materials, EarlyView.
Chamber‐specific decellularized extracellular matrices (ECMs) were developed, preserving native proteomic profiles of ventricular and atrial myocardium. These innate biochemical cues differentially modulate cardiomyocyte subtypes to drive engineered heart tissue development and function, highlighting the importance of incorporating regional ECM cues in
Dong Gyu Hwang, Myungji Kim, Hwanyong Choi, Jinseon Park, Minji Kim, Donghwan Kim, Bo Ram Lee, Jinah Jang   +7 more
wiley   +1 more source

A cost-effective and scalable barcoded library construction method for deep mutational scanning studies. [PDF]

PLoS Biol
Jann J, Gagnon-Arsenault I, Pageau A, Dubé AK, Fijarczyk A, Durand R, Landry CR.   +6 more
europepmc   +1 more source

Simvastatin Restores Uteroplacental Hemodynamics and Trophoblast Function in Obstetric Antiphospholipid Syndrome in a Placenta‐on‐a‐Chip Model

Advanced Healthcare Materials, EarlyView.
Simvastatin mitigates placental hypoperfusion in OAPS by ameliorating abnormal uteromaternal hemodynamics and enhancing trophoblast invasion via optimized endothelial cell interactions under pathological shear stress, as evidenced by results from a placenta‐on‐a‐chip platform.
Hongli Liu, Yuan Wang, Yanjun Cai, Ruixin Guo, Shunhua Liu, Tingting Chen, Tingting Sun, Ruiheng Huo, Tengwei Liu, Qingfeng Lv, Xietong Wang   +10 more
wiley   +1 more source

Unleashing the power of DNA-encoded libraries for challenging targets in drug discovery. [PDF]

Pharm Sci Adv
Du N, Li Y, Lou Q, Zhang G, Li Y, Li Y.
europepmc   +1 more source