Results 141 to 150 of about 2,713,581 (258)

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Harmonizing epidemiological research methodology for atopic dermatitis research: protocol for the EPISTAR international consensus exercise. [PDF]

Skin Health Dis
Keddie SH, Drewitz KP, Abuabara K, Barbarot S, Barta K, Drucker AM, El Khoury J, Faye O, Galvan C, Godse K, Iskandar RJ, Koplin JJ, Mesarič T, Ohya Y, Otrofanowei E, Vestergaard C, Vestergaard C, Wang H, Williams HC, Yew YW, Flohr C, Apfelbacher CJ.   +21 more
europepmc   +1 more source

Improving the reproducibility of findings by updating research methodology. [PDF]

Qual Quant, 2022
Klein J.
europepmc   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Effectiveness of tobacco control policy interventions on tobacco use behaviours and health outcomes based on ITS research methodology: a scoping review. [PDF]

BMJ Open
Shi Y, Qin D, Wang H, Sun L, Gu K.
europepmc   +1 more source

Inculcating research methodology related skills and aptitude amongst medical undergraduates- An interventional study. [PDF]

J Family Med Prim Care, 2022
Shukla S, Acharya S, Acharya N, Singh S, Dolas P.   +4 more
europepmc   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Implementing Cultural Safety in Research Methodology: The Co-Design Process of a Brief Therapeutic Intervention for Aboriginal and Torres Strait Islander Young People Who Engage in Self-Harm and/or Suicidal Behaviours. [PDF]

Aust J Rural Health
D'Mello C, Milroy H, Papageorgiou A, Coleman M, Dudgeon P, Anderson P, Batty D, Lin A.   +7 more
europepmc   +1 more source

Using Facebook Advertisements for Women's Health Research: Methodology and Outcomes of an Observational Study. [PDF]

JMIR Form Res, 2022
Farr DE, Battle DA, Hall MB.
europepmc   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source