Results 121 to 130 of about 2,713,581 (258)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Smartphone-based activity research: methodology and key insights. [PDF]

Front Surg
Turlip RW, Chauhan D, Ahmad HS, Dagli MM, Hu BY, Chung RJ, Ghenbot Y, Gu BJ, Patel N, Kim RJ, Kincaid J, Verma A, Yoon JW.   +12 more
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Impact of a research methodology course emphasizing critical appraisal skills on dental students' clinical decision-making self-efficacy: a single-arm educational intervention. [PDF]

BMC Med Educ
Ahuja D, Parvez A, Batra P, Jose NP, Shetty S, Kalra G.   +5 more
europepmc   +1 more source

The difference between concealment and blinding in clinical trials and why both are important. A reply to Garg and Mickenautsch, BMC Medical Research Methodology (2022) 22:17. [PDF]

BMC Med Res Methodol, 2023
Lyden P, Broderick J, Grotta J, Kwiatkowski T, Levine S, Frankel M, Haley EC, Tilley B.   +7 more
europepmc   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Research methodology education in Europe: a multi-country, cross-disciplinary survey of current practices and perspectives. [PDF]

Res Integr Peer Rev
Kniffert S, Buljan I, Azevedo F, Babinčák P, Batinović L, Evans TR, Garofalo S, Graham C, Groenink L, Ihle M, Klugar M, Kočišová L, Kohút M, Kostomitsopoulos N, Lacey S, Lunić A, Marušić A, Nordström T, Pennington CR, Pizzolato D, Toelch U, Topor M, Vuković M, de Boer MR.   +23 more
europepmc   +1 more source

Brown fat detection by infrared thermography-An invaluable research methodology with noteworthy uncertainties confirmed by a mathematical proof. [PDF]

Endocrinol Diabetes Metab, 2023
Leow MKS.
europepmc   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Assessment of the impact of a structured training program on knowledge of research methodology among anesthesiology trainees at a tertiary referral cancer center. [PDF]

Perspect Clin Res
Sivateja M, Ranganathan P.
europepmc   +1 more source