Results 41 to 50 of about 2,517,674 (258)

Range of Body Mass Index and the risk of breast cancer

Journal of Education, Health and Sport, 2018
Introduction. Obesity leads to an increased incidence of many diseases. The research subject of scientists is the impact of obesity on breast cancer as one of the most commonly diagnosed cancers among women. Aim of the study.
Alicja Sobek, Karol Lorenc, Urszula Fałkowska, Julita Poleszak, Halina Piecewicz-Szczęsna   +4 more
doaj   +3 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Measles – are we dealing with a new epidemy in Poland?

Journal of Education, Health and Sport, 2017
Introduction: In the past few years, a group of parents avoid mandatory vaccination of children has increased. One of the effects of this action is increasing incidence of measles among unvaccinated people.
Maciej Rutkowski, Łukasz Świerszcz, Anna Roszkowska, Anna Taracha, Halina Piecewicz-Szczęsna   +4 more
doaj   +3 more sources

Hepatotoxicity of anabolic androgenic steroids in sport

Journal of Education, Health and Sport, 2020
Introduction and purpose: Anabolic-androgenic steroids (AAS) abuse is a common practice among professional as well as recreational athletes. The prevalence of this phenomenon seems to be continuously escalating, too.
Michał Jakub Sekuła, Blanka Świerczyńska, Krzysztof Smoluchowski, Adrian Undziakiewicz, Halina Piecewicz-Szczęsna   +4 more
doaj   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Beriberi disease – a picture of thiamine deficiency in underdeveloped and highly developed countries

Journal of Education, Health and Sport, 2020
Introduction and purpose: Thiamin (Vitamin B1) is a water-soluble vitamin. It plays an important role in many biological processes, mainly in glucose metabolism. Its deficiency is called beriberi disease.
Agnieszka Blicharz, Magdalena Marzęda, Małgorzara Drozd, Jakub Czarnota, Halina Piecewicz-Szczęsna   +4 more
doaj   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Unclear etiology and current hypotheses of the pathogenesis of fibromyalgia

Journal of Education, Health and Sport, 2020
Introduction and purpose: Fibromyalgia is a chronic condition affecting almost 2% of the general population, mostly women. The main symptoms are chronic diffuse musculoskeletal pain or stiffness, tiredness,  nonrestorative sleep, anxiety, depression and ...
Małgorzata Drozd, Magdalena Marzęda, Agnieszka Blicharz, Jakub Czarnota, Halina Piecewicz-Szczęsna   +4 more
doaj   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source