Results 41 to 50 of about 22,421,622 (338)

What to Do When Medical Evidence Can Only Be Generated Through Routine Data: An Example From Pediatric Oncology

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Children undergoing allogeneic stem cell transplantation often receive off‐label rituximab treatment for Epstein–Barr virus reactivation, using adult dosing without pediatric evidence. This project aims to develop a clinical decision support tool (CDSS) that provides evidence‐based dosing scenarios by analyzing real‐world patient data.
Birgit Burkhardt, Antje Walz, Dietrich Knoerzer   +2 more
wiley   +1 more source

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

The correlation between measles vaccination rate of children in Poland and incidence rate of this disease from 1998 to 2017 and in Italy from 2012 to 2017

Journal of Education, Health and Sport, 2018
Introduction. Measles is a highly contagious disease capable of inducing epidemics, which strike every 2 to 3 years. Before implementing the vaccine in 1963 measles was devastating communities leading to 135 million of victims and 6 million died because ...
Dorota Sokół, Michał Dobrzyński, Arkadiusz Standyło, Tomasz Skubel, Jakub Czarnota, Halina Piecewicz-Szczęsna   +5 more
doaj   +3 more sources

OPTIMIZATION OF THE PRODUCTION STRUCTURE OF FIELD ENERGY CROPS [PDF]

Annals of the University of Oradea: Economic Science, 2016
In our paper we have dealt with the biomass-based energy production during the agricultural production, since the sustainable energy management is one of the most actual issues.
Margit Csipkes, Timea Gal
doaj  

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

The use of lung ultrasound in the diagnosis of pneumothorax in trauma patients

Journal of Education, Health and Sport, 2020
Introduction and purpose: Pneumothorax is a condition in which air is present in the pleural cavity and often has a traumatic etiology. It can be a life-threatening condition, making quick and effective diagnosis essential.
Adrian Undziakiewicz, Michał Sekuła, Krzysztof Smoluchowski, Dorota Sokół, Blanka Świerczyńska, Halina Piecewicz-Szczęsna   +5 more
doaj   +1 more source

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

FEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz, Milagros Siebeck Caturelli, Lina S. Lehmann, Florian Kurth, Alexander G. Maier, Kai Matuschewski   +5 more
wiley   +1 more source

Indigenous research methodology – weaving a research interface

International Journal of Social Research Methodology, 2019
Indigenous research Knowledges and methodologies have existed over millennia, however it is only recently that Indigenous scholars have been able to challenge institutional Western hegemony to reclaim sovereignty in the research space.
C. Ryder, T. Mackean, Julieann Coombs, H. Williams, K. Hunter, A. Holland, R. Ivers   +6 more
semanticscholar   +1 more source

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

Hepatotoxicity of anabolic androgenic steroids in sport

Journal of Education, Health and Sport, 2020
Introduction and purpose: Anabolic-androgenic steroids (AAS) abuse is a common practice among professional as well as recreational athletes. The prevalence of this phenomenon seems to be continuously escalating, too.
Michał Jakub Sekuła, Blanka Świerczyńska, Krzysztof Smoluchowski, Adrian Undziakiewicz, Halina Piecewicz-Szczęsna   +4 more
doaj   +1 more source