Results 61 to 70 of about 7,850,964 (278)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Conditional Power and Model Selection Based Sample Size Reestimation with Type I Error Recalibration

Epidemiology, Biostatistics and Public Health
Introduction The sample size estimation at study design depends on initial assumptions regarding the target power, treatment effect, accrual/follow-up duration and the underlying exponential distribution for time-to-event outcomes.
Michele Pio Di Palma, Francesca Galli , Eliana Rulli   +2 more
doaj   +1 more source

Research Methodology Through Writing Research Proposal Retrospectively by Combining Classroom Discussion and Collaborative Working Group in Lesson Study [PDF]

, 2015
Lesson Study (LS) was conducted aiming at: (1) describing the ideal steps in combining classroom discussion and collaborative working group in effort to improve students' comprehension on writing biology research proposal that is arranged retrospectively;
Hindun, I. (Iin), Husamah, H. (Husamah), Purwanti, E. (Ely), Rofieq, A. (Ainur), Wahyuni, S. (Sri)   +4 more
core  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Range of Body Mass Index and the risk of breast cancer

Journal of Education, Health and Sport, 2018
Introduction. Obesity leads to an increased incidence of many diseases. The research subject of scientists is the impact of obesity on breast cancer as one of the most commonly diagnosed cancers among women. Aim of the study.
Alicja Sobek, Karol Lorenc, Urszula Fałkowska, Julita Poleszak, Halina Piecewicz-Szczęsna   +4 more
doaj   +3 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Measles – are we dealing with a new epidemy in Poland?

Journal of Education, Health and Sport, 2017
Introduction: In the past few years, a group of parents avoid mandatory vaccination of children has increased. One of the effects of this action is increasing incidence of measles among unvaccinated people.
Maciej Rutkowski, Łukasz Świerszcz, Anna Roszkowska, Anna Taracha, Halina Piecewicz-Szczęsna   +4 more
doaj   +3 more sources

Web crawler research methodology [PDF]

In economic and social sciences it is crucial to test theoretical models against reliable and big enough databases. The general research challenge is to build up a well-structured database that suits well to the given research question and that is cost ...
Nemeslaki, András, Pocsarovszky, Károly   +1 more
core  

Empirical Challenges in Organizational Aesthetics Research: Towards a Sensual Methodology [PDF]

, 2008
Despite growing scholarly interest in aesthetic dimensions of organizational life, there is a lack of literature expressly engaging with the methodological mechanics of 'doing aesthetics research'. This article addresses that gap.
Alfonso, Ana-Isobel, Bauman, Zygmunt, Bourdieu, Pierre, Candlin, Fiona, Cohen, Laurie, Collier, John, Corbett, Martin, Guillet de Monthoux, Pierre, Hurworth, Rosalind, Kvale, Steinar, Langer, Suzanne, Linstead, Stephen, Parker, Lee, Pink, Sarah, Pink, Sarah, Pink, Sarah, Ramirez, Rafael, Rehn, Alf, Samantha Warren, Schroeder, Jonathan, Scott, Clive., Strangleman, Tim, Strati, Antonio, Strati, Antonio, Warburton, Nigel, Warren, Samantha, Warren, Samantha, Warren, Samantha, Welsch, Wolfgang, Willis, Paul, Willis, Paul, Witkin, Robert   +31 more
core   +1 more source