Results 61 to 70 of about 26,805,984 (378)

The multidrug and toxin extrusion (MATE) transporter DTX51 antagonizes non‐cell‐autonomous HLS1–AMP1 signaling in a region‐specific manner

FEBS Letters, EarlyView.
The Arabidopsis mutants hls1 hlh1 and amp1 lamp1 exhibit pleiotropic developmental phenotypes. Although the functions of the causative genes remain unclear, they act in the same genetic pathway and are thought to generate non‐cell‐autonomous signals.
Takashi Nobusawa, Makoto Kusaba
wiley   +1 more source

The use of lung ultrasound in the diagnosis of pneumothorax in trauma patients

Journal of Education, Health and Sport, 2020
Introduction and purpose: Pneumothorax is a condition in which air is present in the pleural cavity and often has a traumatic etiology. It can be a life-threatening condition, making quick and effective diagnosis essential.
Adrian Undziakiewicz, Michał Sekuła, Krzysztof Smoluchowski, Dorota Sokół, Blanka Świerczyńska, Halina Piecewicz-Szczęsna   +5 more
doaj   +1 more source

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

FEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer, Philip Hinchliffe, Marko Hanževački, Christopher R. Bethel, Catherine L. Tooke, Marc W. Van der Kamp, Krisztina M. Papp‐Wallace, Robert A. Bonomo, Stuart Shapiro, Adrian J. Mulholland, James Spencer   +10 more
wiley   +1 more source

Unclear etiology and current hypotheses of the pathogenesis of fibromyalgia

Journal of Education, Health and Sport, 2020
Introduction and purpose: Fibromyalgia is a chronic condition affecting almost 2% of the general population, mostly women. The main symptoms are chronic diffuse musculoskeletal pain or stiffness, tiredness,  nonrestorative sleep, anxiety, depression and ...
Małgorzata Drozd, Magdalena Marzęda, Agnieszka Blicharz, Jakub Czarnota, Halina Piecewicz-Szczęsna   +4 more
doaj   +1 more source

Beyond Action Research. The communicative Methodology of Research [PDF]

, 2017
In this article we show how the communicative methodology of research (CMR) makes it possible to implement evidence-based policies to improve people's lives.
Capllonch Bujosa, Marta, Elboj Saso, Carmen, Gómez González, Aitor   +2 more
core   +1 more source

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

FEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura, Lixiang Wang, Nao Hasuzawa, Ayako Nagayama, Sawako Moriyama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +8 more
wiley   +1 more source

Beriberi disease – a picture of thiamine deficiency in underdeveloped and highly developed countries

Journal of Education, Health and Sport, 2020
Introduction and purpose: Thiamin (Vitamin B1) is a water-soluble vitamin. It plays an important role in many biological processes, mainly in glucose metabolism. Its deficiency is called beriberi disease.
Agnieszka Blicharz, Magdalena Marzęda, Małgorzara Drozd, Jakub Czarnota, Halina Piecewicz-Szczęsna   +4 more
doaj   +1 more source

Phenomenological Research Methodology

Scientific Research Journal, 2019
The phenomenological research methodology relates to several approaches that in turn, they are applied to single cases or to the deliberate samples that are carefully chosen.
Neville Greening
semanticscholar   +1 more source

Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1

FEBS Letters, EarlyView.
Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri, Andrea Lapucci, Giuseppe Orsomando, Nadia Raffaelli, Alberto Chiarugi, Daniela Buonvicino   +5 more
wiley   +1 more source

The correlation between tuberculosis and diabetes incidence and the impact of mass migration on the development of tuberculosis and drug-resistant tuberculosis on the example of India and England

Journal of Education, Health and Sport, 2019
Introduction: Tuberculosis is still a major health concern around the world, especially in developing countries with very large populations. Diabetes may be responsible for the progression of Mycobacterium tuberculosis infection.
Dorota Sokół, Arkadiusz Standyło, Jakub Czarnota, Tomasz Skubel, Michał Dobrzyński, Halina Piecewicz-Szczęsna   +5 more
doaj   +3 more sources