Results 131 to 140 of about 2,566,888 (342)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

An Exposition of Research Methodology in Management and Social Sciences

Journal of Economic Development, Environment and People, 2013
In writing this paper the author has consciously stood apart from his earlier works and attempted to dispassionately review his own position so that some degree of clarity of thought might emerge in the process.
Sorab Sadri
doaj  

The role of artificial intelligence for early warning systems: Status, applicability, guardrails, and ways forward

iScience
Summary: Artificial intelligence (AI) is gaining momentum in earth sciences as a tool to analyze complex natural hazards and their impacts. Such analyses are critical for effective Early Warning Systems (EWSs), which is aiming to generate timely and ...
Timothy Tiggeloven, Samira Pfeiffer, Alessia Matanó, Marc van den Homberg, Lisa Thalheimer, Markus Reichstein, Silvia Torresan   +6 more
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Awareness of Research Methodology in Social Sciences

RESEARCH HUB International Multidisciplinary Research Journal
Research is inevitable for the professionals for their career growth and for the cause of the society. Research must be done in systemic and righteous manner so that it augments the understanding of the real problem and facilitates the solution of the problems under consideration. It is important to have a deep understanding of research methodology for
openaire   +1 more source

Multiple Methods, Communicative Preferences and the Incremental Interview Approach Protocol

Forum: Qualitative Social Research, 2009
This article introduces a multiple methods data collection protocol. The protocol has been designed mainly for those unsure of the practical steps needed to insure coherent data-sets with respect to the substantive, theoretical and methodological issues ...
David M. Hoffman
doaj  

Algorithmic aesthetics: Cognitive perspectives on AI-generated visual art

iScience
Summary: In recent years, the use of generative artificial intelligence has proliferated across various domains, ranging from advertising and social media to the generation of visual artwork for presentation at esteemed art exhibitions and for sale on ...
Ionela Bara, Kohinoor M. Darda, Richard Ramsey, Emily S. Cross   +3 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Communicating the interdependence of human, animal, and environmental health on X (formerly Twitter): Insights from the one health approach

iScience
Summary: The COVID-19 pandemic has underscored societies’ need for education and preparedness in addressing global environmental and health crises. Raising public awareness of the interdependence of human, animal, and environmental health is essential to
Juan M. Requena-Mullor, Enrica Garau, María D. López-Rodríguez, Cristina Quintas-Soriano, Antonio J. Castro Martínez   +4 more
doaj   +1 more source