Results 131 to 140 of about 1,735,729 (314)

Early warning of regime switching in a complex financial system from a spillover network dynamic perspective

iScience
Summary: Early warning of regime switching in a complex financial system is a critical and challenging issue in risk management. Previous research has examined regime switching through analyzing the fluctuation features in a single point in time series ...
Sufang An, Xiangyun Gao, Feng An, Tao Wu
doaj  

Joint Latent Space Model for Social Networks with Multivariate Attributes [PDF]

arXiv, 2019
In many application problems in social, behavioral, and economic sciences, researchers often have data on a social network among a group of individuals along with high dimensional multivariate measurements for each individual. To analyze such networked data structures, we propose a joint Attribute and Person Latent Space Model (APLSM) that summarizes ...
arxiv  

Peripheral blood leukocyte signatures as biomarkers in relapsed ovarian cancer patients receiving combined anti‐CD73/anti‐PD‐L1 immunotherapy in arm A of the NSGO‐OV‐UMB1/ENGOT‐OV30 trial

Molecular Oncology, EarlyView.
Using mass cytometry, we analyzed serial blood samples from patients with relapsed epithelial ovarian cancer (EOC) treated with oleclumab–durvalumab combination immunotherapy in the NSGO‐OV‐UMB1/ENGOT‐OV30 trial. Our analysis identified potential predictive, monitoring, and response biomarkers detectable through liquid biopsy. These findings facilitate
Luka Tandaric, Annika Auranen, Katrin Kleinmanns, René DePont Christensen, Liv Cecilie Vestrheim Thomsen, Cara Ellen Wogsland, Emmet McCormack, Johanna Mäenpää, Kristine Madsen, Karen Stampe Petersson, Mansoor Raza Mirza, Line Bjørge   +11 more
wiley   +1 more source

Response to neoadjuvant chemotherapy in early breast cancers is associated with epithelial–mesenchymal transition and tumor‐infiltrating lymphocytes

Molecular Oncology, EarlyView.
Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.
Françoise Derouane, Jérôme Ambroise, Cédric van Marcke, Mieke Van Bockstal, Martine Berlière, Christine Galant, Hélène Dano, Médina Lougué, Elena Benidovskaya, Guy Jerusalem, Vincent Bours, Claire Josse, Jérôme Thiry, Aurélie Daumerie, Caroline Bouzin, Cyril Corbet, François P. Duhoux   +16 more
wiley   +1 more source

Intelligent Computing Social Modeling and Methodological Innovations in Political Science in the Era of Large Language Models [PDF]

arXiv
The recent wave of artificial intelligence, epitomized by large language models (LLMs), has presented opportunities and challenges for methodological innovation in political science, sparking discussions on a potential paradigm shift in the social sciences.
arxiv  

Social Science Methodologies for Studying Individuals' Responses in Human Issues in Horticulture Research [PDF]

, 2000
Candice A. Shoemaker, Paula Diane Relf, Virginia I. Lohr   +2 more
openalex   +1 more source

Targeting PRAME directly or via EZH2 inhibition overcomes retinoid resistance and represents a novel therapy for keratinocyte carcinoma

Molecular Oncology, EarlyView.
The study evaluated the function and therapeutic implications of PRAME in basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The findings demonstrate that PRAME impairs keratinocyte differentiation pathways. Furthermore, PRAME impairs anticancer response to retinoid compounds in BCC and SCC cells.
Brandon Ramchatesingh, Amelia Martinez Villarreal, Philippe Lefrançois, Jennifer Gantchev, Sriraam Sivachandran, Samy Abou Setah, Ivan V. Litvinov   +6 more
wiley   +1 more source

A 7,000-year-old multi-component arrow poison from Kruger Cave, South Africa

iScience
Summary: We present the results of a GC-MS and UHPLC-MS analysis of residue recovered from the marrow cavity of a 7,000-year-old bovid femur from Kruger Cave, South Africa.
Justin Bradfield, Ian A. Dubery, Paul A. Steenkamp   +2 more
doaj  

Del rigor en la Ciencia Política: algunas reflexiones sobre metodología de la investigación.

Colombia Internacional, 2007
During the first semester of 2006, political science students from the University of the Andes held their second symposium. One of the papers presented and its corresponding critique made by one of the department’s professors is here transcribed.
Santiago Olivella
doaj  

Bayes factor testing of equality and order constraints on measures of association in social research [PDF]

arXiv, 2018
Measures of association play a central role in the social sciences to quantify the strength of a linear relationship between the variables of interest. In many applications researchers can translate scientific expectations to hypotheses with equality and/or order constraints on these measures of association.
arxiv