Results 111 to 120 of about 1,952,261 (305)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Understanding mariners’ tsunami information needs and decision-making contexts: A post-event case study of the 2022 Tonga eruption and tsunami

iScience
Summary: The 15 January 2022, Hunga Tonga Hunga Ha’apai volcanic eruption generated a tsunami that spread across the Pacific Ocean and prompted a tsunami advisory in Aotearoa New Zealand (NZ).
Sara E. Harrison, Rachel V. Lawson, Lucy Kaiser, Sally H. Potter, David Johnston   +4 more
doaj   +1 more source

Forecasting a Language Shift Based on Cellular Automata [PDF]

Language extinction as a consequence of language shifts is a widespread social phenomenon that affects several million people all over the world today.
Doris Ferreres, Francesc S. Beltran, Marc-Antoni Adell, Marcos Ruiz-Soler, Salvador Herrando, Violant Estreder   +5 more
core  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Qualitative and Quantitative Research: A Review of the Why and the How to Gain Knowledge About the Social

Universitas Humanística, 2007
The main source of difficulties we find in social sciences to accumulate knowledge comes from fusioning the question of what to research with the question of how to solve research questions.
Juan Camilo Plata Caviedes
doaj  

Rhizome connections... [PDF]

, 2004
There are a number of papers in the journal that reflect a trend in environmental education towards deliberating recuperative, relational epistemologies.
Lotz-Sisitka, Heila 1965-
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

An Exposition of Research Methodology in Management and Social Sciences

Journal of Economic Development, Environment and People, 2013
In writing this paper the author has consciously stood apart from his earlier works and attempted to dispassionately review his own position so that some degree of clarity of thought might emerge in the process.
Sorab Sadri
doaj  

The role of artificial intelligence for early warning systems: Status, applicability, guardrails, and ways forward

iScience
Summary: Artificial intelligence (AI) is gaining momentum in earth sciences as a tool to analyze complex natural hazards and their impacts. Such analyses are critical for effective Early Warning Systems (EWSs), which is aiming to generate timely and ...
Timothy Tiggeloven, Samira Pfeiffer, Alessia Matanó, Marc van den Homberg, Lisa Thalheimer, Markus Reichstein, Silvia Torresan   +6 more
doaj   +1 more source

Awareness of Research Methodology in Social Sciences

RESEARCH HUB International Multidisciplinary Research Journal
Research is inevitable for the professionals for their career growth and for the cause of the society. Research must be done in systemic and righteous manner so that it augments the understanding of the real problem and facilitates the solution of the problems under consideration. It is important to have a deep understanding of research methodology for
openaire   +1 more source