Results 91 to 100 of about 1,952,261 (305)
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
, 2014 There are many digital tools that can be used for research and presentation in nearly every college discipline, including the social sciences and humanities. These tools hold the promise to radically change both the process and products of research.
Kann, Charles W.
core
LEGAL RESEARCH METHODOLOGY AND THE DREAM OF INTERDISCIPLINARITY [PDF]
, 2013 There are increasing calls for academics to abandon "traditional" disciplinary research and to engage in multi-, inter- and transdisciplinary research.
Irma J Kroeze
core +2 more sources
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Understanding Qualitative Research Methodology: A Systematic Review [PDF]
E-Journal of Humanities, Arts and Social SciencesAs novice researchers and supervisors, the researchers of the current study have noticed that many postgraduate students encounter challenges in understanding qualitative research methodology.
David Seetsa Makateng +1 more
doaj +1 more source
Memahami Metode Kualitatif [PDF]
, 2005 Qualitative method has been widely be adopted in research practices in Indonesian tradition of social sciences including sociology. However, it seems there is misunderstanding on the method that is seen as additional to the quantitative one.
Somantri, G. R. (Gumilar)
core +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Ethical Dilemma and Research Methodology of Social Sciences
Bangladesh Journal of Bioethics, 1970 DOI: http://dx.doi.org/10.3329/bioethics.v1i1.9529 Bangladesh Journal of Bioethics 2010; 1(1 ...
openaire +2 more sources
Mapping Diversity of Publication Patterns in the Social Sciences and Humanities: An Approach Making Use of Fuzzy Cluster Analysis [PDF]
, 2016 <b>Purpose:</b> To present a method for systematically mapping diversity of publication patterns at the author level in the social sciences and humanities in terms of publication type, publication language and co-authorship.<br><b ...
Arie Weeren +2 more
core +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source