Results 91 to 100 of about 67,249,689 (312)

Journal of Methodology of Social Sciences and Humanities; No. 109

Study of the relationship between philosophy, philosophy of social sciences and humanities, methodology and research method; The role of philosophy and methodology of social sciences and humanities in the quantitative and qualitative improvement of ...
Methodology of Social Sciences and Humanities, J (via Mendeley Data)
core   +1 more source

Understanding Qualitative Research Methodology: A Systematic Review [PDF]

E-Journal of Humanities, Arts and Social Sciences
As novice researchers and supervisors, the researchers of the current study have noticed that many postgraduate students encounter challenges in understanding qualitative research methodology.
David Seetsa Makateng , Ntsoaki Teresa Mokala   +1 more
doaj   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Journal of Methodology of Social Sciences and Humanities; No. 112

Study of the relationship between philosophy, philosophy of social sciences and humanities, methodology and research method; The role of philosophy and methodology of social sciences and humanities in the quantitative and qualitative improvement of the ...
Methodology of Social Sciences and Humanities, J (via Mendeley Data)
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Screenathon 2.0: human–AI collaborative screening applied to patient-generated health data

Scientific Reports
Systematic reviews are essential for evidence-based research, yet the traditional screening process is time-consuming and difficult to scale. Human-only screening can introduce inconsistency, while fully automated approaches employing Large Language ...
Jonas Bergmann, Tiago Azzi, Rutger Neeleman, Kianush Monschau, Berke Yazan, Elena Jalsovec, Emily Westerbeek, Felix Weijdema, Jonathan de Bruin, Qixiang Fang, Rens van de Schoot   +10 more
doaj   +1 more source

Challenges of naturalism in social science methodology [PDF]

حکمت و فلسفه
This article examines and discusses the application of naturalistic methodology in social sciences and the challenges facing this methodology. Social science methodology faces a fundamental question; whether the application of natural science methodology
payam fazli
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Del rigor en la Ciencia Política: algunas reflexiones sobre metodología de la investigación.

Colombia Internacional, 2007
During the first semester of 2006, political science students from the University of the Andes held their second symposium. One of the papers presented and its corresponding critique made by one of the department’s professors is here transcribed.
Santiago Olivella
doaj  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source