Results 71 to 80 of about 67,249,689 (312)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Journal of Methodology of Social Sciences and Humanities; No. 111

Study of the relationship between philosophy, philosophy of social sciences and humanities, methodology and research method; The role of philosophy and methodology of social sciences and humanities in the quantitative and qualitative improvement of ...
Methodology of Social Sciences and Humanities, J (via Mendeley Data)
core   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Journal of Methodology of Social Sciences and Humanities; No.84

Study of the relationship between philosophy, philosophy of social sciences and humanities, methodology and research method; The role of philosophy and methodology of social sciences and humanities in the quantitative and qualitative improvement of ...
Methodology of Social Sciences and Humanities, J (via Mendeley Data)
core   +1 more source

Sample Size Determination Techniques for Behavioral Sciences Research

Journal of Humanities and Social Sciences Mahasarakham University, 2023
The purposes of this article are to inform readers about. - 1) how to gain better understanding regarding the sample size techniques for behavioral science research, 2) know how to determine the sample size for classical behavioral sciences ...
Rungson Chomeya, Sombat Tayraukham
doaj  

Conceptual and Methodological Research of Xenophobia in Social Sciences

Mediterranean Journal of Social Sciences, 2015
The article presents a conceptual and methodological analysis of xenophobia study in social sciences. In order to investigate the phenomenon of xenophobia, the authors propose to use the methodology of constructive realism that makes it possible to substantiate the social nature of criteria for defining the "outsiders" and their dynamics.
Vladimir Alexandrovich Kirik, Alexander Vladimirovich Popov, Oxana Yuryevna Posukhova, Anton Vladimirovich Serikov, Olga Mikhailovna Shevchenko   +4 more
openaire   +2 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Journal of Methodology of Social Sciences and Humanities; No.118

Study of the relationship between philosophy, philosophy of social sciences and humanities, methodology and research method; The role of philosophy and methodology of social sciences and humanities in the quantitative and qualitative improvement of ...
Methodology of Social Sciences and Humanities, J (via Mendeley Data)
core   +1 more source

Search advantages for facing social groups reflect optimal interactive group sizes

iScience
Summary: Humans are sensitive to the presence of other people as well as their interactions. For example, two individuals are found faster when they face toward (vs. away from) each other.
Luowei Yan, Clara Colombatto, Jelena Ristic   +2 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source