Results 51 to 60 of about 1,952,261 (305)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Observational studies of exposure to tobacco and nicotine products: Best practices for maximizing statistical precision and accuracy

iScience
Summary: Non-randomized observational studies can track risk-induction and -reduction associated with real-world use of non-combusted nicotine and tobacco products.
Gal Cohen, Steven Cook
doaj   +1 more source

Cultural representations of mental illness in contemporary Japan [PDF]

, 2014
This paper presents the results of a research project aimed at studying the cultural representations of mental illness and related interventions models in contemporary Japan, and providing the basis for a comparison between Japanese and Italian mental ...
Bucci, Fiorella
core  

Quantifying human subjectivity using Q method : when quality meets quantity [PDF]

, 2014
Incorporating human subjectivity in applied disciplines of social sciences and other base sciences poses a challenge as the nature of qualitative data is often the point of contention.
Grodzińska-Jurczak, Małgorzata, Kamal, Sristi, Kocór, Marcin   +2 more
core   +2 more sources

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

The impact of the COVID-19 pandemic on enrollment in undergraduate health-related studies in Spain

BMC Medical Education, 2023
The aim of this study was to determine whether the pandemic has reinforced the choice of pursuing health-related bachelor’s degrees, and to identify underlying factors that could contribute to that impact.
Jaume-Miquel March-Amengual, Irene Cambra-Badii, Consolación Pineda Galán, Ester Busquets-Alibés, Montse Masó Aguado, Anna Ramon-Aribau, Lydia Feito Grande, Agustí Comella Cayuela, Nuria Terribas i Sala, Elena Andrade-Gómez, Naiara Martínez-Perez, Javier Jerez-Roig   +11 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Expectations guide predictive eye movements and information sampling during face recognition

iScience
Summary: Context information has a crucial impact on our ability to recognize faces. Theoretical frameworks of predictive processing suggest that predictions derived from context guide sampling of sensory evidence at informative locations. However, it is
Annika Garlichs, Mark Lustig, Matthias Gamer, Helen Blank   +3 more
doaj   +1 more source

Adolescents from low-income sectors: the challenge of studying in a time of digital environments [PDF]

, 2014
This paper is about practices and perceptions regarding the study of adolescents from low-income sectors in the City of Buenos Aires. The methodology consisted of 26 in-depth interviews with low-income adolescents and participant observations in twenty ...
Linne, Joaquín Walter
core   +1 more source