An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
Measuring the vitality and effectiveness within social sciences and humanities research. an attempt in Italian LIS studies [PDF]
, 2016 This study constitutes the beginning of a PhD research in Library and information science at Sapienza University of Rome, aimed at investigating the level of internationalisation, vitality and effectivenessof Italian Library and ...
TURBANTI, SIMONA
core
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Do You See what I See? Tracking the Perceptual Beliefs of Robots
iScience, 2020 Summary: Keeping track of others' perceptual beliefs—what they perceive and know about the current situation—is imperative in many social contexts. In a series of experiments, we set out to investigate people's ability to keep track of what robots know ...
Sam Thellman, Tom Ziemke
doaj +1 more source
Open Science Practices are on the Rise: The State of Social Science (3S) Survey [PDF]
, 2020 Has there been meaningful movement toward open sci-ence practices within the social sciences in recent years? Discussions about changes in practices such as posting data and pre-registering analyses have been marked by controversy—including controversy ...
Birke, David +6 more
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Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Integration of cognitive tasks into artificial general intelligence test for large models
iScienceSummary: During the evolution of large models, performance evaluation is necessary for assessing their capabilities. However, current model evaluations mainly rely on specific tasks and datasets, lacking a united framework for assessing the ...
Youzhi Qu +12 more
doaj +1 more source
Does Germany Need a (New) Research Ethics for the Social Sciences? [PDF]
This paper evaluates the German, UK, and US approaches to dealing with research ethics in the social sciences. It focuses 1) on the extent to which these research ethic frameworks protect the key rights of research subjects and 2) the extent to to which ...
Claudia Oellers, Eva Wegner
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Reshaping Academic Practice and Relationships within the Department Of Plant Sciences [PDF]
, 2007 At the University of Cambridge, a research and development project concerned with teaching and learning in small-group tutorials has been initiated in Department of Plant Sciences.
Johnstone, Keith +2 more
core +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source