Results 81 to 90 of about 1,952,261 (305)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Sample Size Determination Techniques for Behavioral Sciences Research

Journal of Humanities and Social Sciences Mahasarakham University, 2023
The purposes of this article are to inform readers about. - 1) how to gain better understanding regarding the sample size techniques for behavioral science research, 2) know how to determine the sample size for classical behavioral sciences ...
Rungson Chomeya, Sombat Tayraukham
doaj  

A methodological approach to evaluate elderly-robot interactions [PDF]

, 2018
The relevance in the study of interaction between elderly and robots may depend on the choice of activities that robots can be developed to perform and the assessment of their impact and importance for older people.
Gonçalves, Paulo, Moreira, Maria João, Pereira, Cristina, Pinheira, Vítor, Silva, Simão   +4 more
core  

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Search advantages for facing social groups reflect optimal interactive group sizes

iScience
Summary: Humans are sensitive to the presence of other people as well as their interactions. For example, two individuals are found faster when they face toward (vs. away from) each other.
Luowei Yan, Clara Colombatto, Jelena Ristic   +2 more
doaj   +1 more source

Voicing the Less Heard: A Review of Focus Group Methodology: Principles and Practice [PDF]

, 2011
Focus Group Methodology: Principles and Practice is a powerful text in not only equipping novice researchers with all the stages of designing a focus group, but also facilitating their understanding of the philosophies and in-depth principles of focus ...
Kulavuz-Onal, Derya
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The (non)-effect of the knowledge era on undergraduate research methodology curricula in the social sciences

SA Journal of Industrial Psychology, 2005
Educational policy reform in South Africa seeks to address the real-life relevance of curricula, and specifically, reformists have turned to proponents of Mode 2 knowledge to inform initiatives for change.
Claire Wagner, David J. F. Maree
doaj   +1 more source

Using agent based simulation to empirically examine complexity in carbon footprint business process [PDF]

, 2009
Through the critical analysis of the extant literature, it is observed that Simulation is widely used as a research method in Natural Sciences, Engineering and Social Sciences, in addition to argumentation and formalisation as the third way of carrying ...
Khan, T, Patel, NV, Pilla, VN
core