Results 81 to 90 of about 429,366 (262)

Del rigor en la Ciencia Política: algunas reflexiones sobre metodología de la investigación.

Colombia Internacional, 2007
During the first semester of 2006, political science students from the University of the Andes held their second symposium. One of the papers presented and its corresponding critique made by one of the department’s professors is here transcribed.
Santiago Olivella
doaj  

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Qualitative and Quantitative Research: A Review of the Why and the How to Gain Knowledge About the Social

Universitas Humanística, 2007
The main source of difficulties we find in social sciences to accumulate knowledge comes from fusioning the question of what to research with the question of how to solve research questions.
Juan Camilo Plata Caviedes
doaj  

Understanding mariners’ tsunami information needs and decision-making contexts: A post-event case study of the 2022 Tonga eruption and tsunami

iScience
Summary: The 15 January 2022, Hunga Tonga Hunga Ha’apai volcanic eruption generated a tsunami that spread across the Pacific Ocean and prompted a tsunami advisory in Aotearoa New Zealand (NZ).
Sara E. Harrison, Rachel V. Lawson, Lucy Kaiser, Sally H. Potter, David Johnston   +4 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

The role of artificial intelligence for early warning systems: Status, applicability, guardrails, and ways forward

iScience
Summary: Artificial intelligence (AI) is gaining momentum in earth sciences as a tool to analyze complex natural hazards and their impacts. Such analyses are critical for effective Early Warning Systems (EWSs), which is aiming to generate timely and ...
Timothy Tiggeloven, Samira Pfeiffer, Alessia Matanó, Marc van den Homberg, Lisa Thalheimer, Markus Reichstein, Silvia Torresan   +6 more
doaj   +1 more source

Research traditions in social sciences and their methodological rationales

Aloma: Revista de Psicologia, Ciències de l'Educació i de l'Esport, 2018
The aim of this article is to review and describe the most common research paradigms in social sciences in order to then use this knowledge to inform the choice of research methods. Paradigms are defined here as traditions generated by the diversity of ways of understanding reality and the associated beliefs about what knowledge is and how it can be ...
openaire   +3 more sources