Results 91 to 100 of about 66,179,807 (296)
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Assessment of research methods training needs among UK academic social scientists [PDF]
, 2011 This training needs assessment comprised an online survey of academic social scientists and a content analysis of academic social scientist job specifications.
Wiles, Rose, Moley, Sean
core +1 more source
Psychometric Evaluation of the HIV Knowledge Questionnaire-18 in a Black Canadian Population
HIV/AIDS: Research and Palliative CareAgatha Nyambi,1 Elizabeth Alvarez,1 Laura N Anderson,1 Fatimah Jackson-Best,1 Wangari Tharao,2 Egbe B Etowa,3 Shamara Baidoobonso,4 Maureen Owino,5 Pascal Djiadeu,1 Daeria O Lawson,1 Lawrence Mbuagbaw1,6– 10 1Department of Health Research Methods ...
Nyambi A +10 more
doaj
BMC Infectious DiseasesBackground Antibiotics are broadly prescribed for community-acquired pneumonia (CAP) despite being only effective for bacterial infections. LIAISON® MeMed BV® (LMMBV) is a novel diagnostic test that can support clinicians in differentiating bacterial ...
Brittany Humphries +3 more
doaj +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
, 2017 In this paper, we discuss the opportunities and challenges of comparative research. We outline the major obstacles in terms of building a comparative theoretical framework, collecting good quality data and analyzing those data, but also explicate the advantages and research questions that can be addressed when taking a comparative approach ...
Esser, Frank, Vliegenthart, Rens
openaire +4 more sources
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
NCRM Bitesize Lessons for Teaching Social Science Research Methods 3: Learning from Learners [PDF]
, 2023 This document is the third guide in the series NCRM Bitesize Lessons for Teaching Social Science Research Methods. It focuses on learning from learners.
Nind, Melanie
core