Results 111 to 120 of about 12,197,949 (364)

Model-based cost-impact analysis of a diagnostic test for patients with community-acquired pneumonia in Canada

open access: yesBMC Infectious Diseases
Background Antibiotics are broadly prescribed for community-acquired pneumonia (CAP) despite being only effective for bacterial infections. LIAISON® MeMed BV® (LMMBV) is a novel diagnostic test that can support clinicians in differentiating bacterial ...
Brittany Humphries   +3 more
doaj   +1 more source

A brief history of the National Centre for Research Methods [PDF]

open access: yes
The National Centre for Research Methods (NCRM) is celebrating its 20th anniversary in 2024. This video timeline provides an overview of some of the centre's key milestones over the past two decades.
Grover, Ed
core  

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Protocol for a systematic review and meta-analysis investigating the impact of continuous versus intermittent enteral feeding in critically ill patients

open access: yesSystematic Reviews
Introduction Enteral nutrition (EN) is the recommended nutritional support in most critically ill populations. When given by feeding tube, EN may be administered either continuously or intermittently.
Lydia S. Acharya   +8 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

JD Carpentieri on qualitative research and theory [PDF]

open access: yes, 2023
In this episode of the Methods podcast, host Catherine McDonald talks to JD Carpentieri, Associate Professor of Social Science and Policy in the Department of Education, Practice and Society at University College London, and an Honorary Research ...
Carpentieri, JD, McDonald, Catherine
core  

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

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