Results 131 to 140 of about 87,581,544 (292)

Research methods in psychology

Fresh, friendly and accessible, this book makes psychology research methods come alive. Calmly steering readers through the research process, it covers all stages – from theory, generating research topics and being an ethical researcher to data ...
Earnshaw, Deborah, Parker, Samuel, Brookfield, Charlotte   +2 more
core   +1 more source

Generative artificial intelligence models outperform students on divergent and convergent thinking assessments

Scientific Reports
Generative artificial intelligence (GenAI) has garnered significant attention for its remarkable capabilities and is now widely used in many creative domains, sparking scientific interest in its creative capacities.
Vikram Arora, Alex Thabane, Sameer Parpia, Goran Calic, Mohit Bhandari   +4 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Spectroscopic aspects of underwater digital holography of plankton

Scientific Reports
Monitoring the parameters and behavior of plankton makes it possible to assess the state of the aquatic ecosystem and detect the beginning of an environmental disaster at an early stage.
Victor Dyomin, Igor Polovtsev, Alexandra Davydova, Nikolai Kirillov   +3 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Evaluating methods for risk prediction of Covid-19 mortality in nursing home residents before and after vaccine availability: a retrospective cohort study

BMC Medical Research Methodology
Background SARS-CoV-2 vaccines are effective in reducing hospitalization, COVID-19 symptoms, and COVID-19 mortality for nursing home (NH) residents.
Komal Aryal, Fabrice I. Mowbray, Anna Miroshnychenko, Ryan P. Strum, Darly Dash, Michael P. Hillmer, Kamil Malikov, Andrew P. Costa, Aaron Jones   +8 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Research Methods in Psychiatry [PDF]

The Canadian Journal of Psychiatry, 1990
openaire   +2 more sources