Results 141 to 150 of about 12,197,949 (364)
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Mixing Research Methods in an Impact Evaluation in Pakistan
, 2016 Mixed-methods research for evaluation, combining qualitative and quantitative approaches, is widely recognized for its potential. It also poses challenges, especially for NGOs with limited resources and capacity for undertaking complex programmes of ...
Mager, Franziska
core +1 more source
, 2017 In this paper, we discuss the opportunities and challenges of comparative research. We outline the major obstacles in terms of building a comparative theoretical framework, collecting good quality data and analyzing those data, but also explicate the advantages and research questions that can be addressed when taking a comparative approach ...
Esser, Frank, Vliegenthart, Rens
openaire +4 more sources
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
International journal of social research methodology lecture: The vicissitudes of methods
, 2012 This talk was presented at the 5th ESRC Research Methods Festival in July ...
Abbott, Andrew
core
Research Methods: Tips & Tricks playlist
, 2017 Research Shorts are short research video summaries by George Veletsianos and The Digital Learning and Social Media Research Group: http://www.thedlrgroup.com/. Research Shorts examine issues relevant to educational technology, digital learning, networked
Veletsianos, George +1 more
core +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
NCRM podcast: The 'Thing-ness' problem of mixed methods research
, 2014 Is mixed methods research a turbulent environment and is innovation being stifled by an overly tightly bound concept of what it is? Sharlene Hesse-Biber, professor in the Sociology Department of Boston College thinks so.
Hesse-Biber, Sharlene
core
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source