Results 121 to 130 of about 87,581,544 (292)
Qualitative methods in socio-spatial research
, 2014 This chapter explores the rationale for qualitative methods, the origins of qualitative research, and a number of important issues relating to the conduct of qualitative research.
O'Neill, Phillip (R11614) +1 more
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Innovative approaches to methodological challenges facing ageing cohort studies [PDF]
, 2013 Ageing cohort studies around the world face common methodological challenges of data collection, measurement and analysis, which become increasingly problematic as participants grow older.
Chandola, Tarani, O'Shea, Susan
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NCRM podcast: The 'Thing-ness' problem of mixed methods research
, 2014 Is mixed methods research a turbulent environment and is innovation being stifled by an overly tightly bound concept of what it is? Sharlene Hesse-Biber, professor in the Sociology Department of Boston College thinks so.
Hesse-Biber, Sharlene
core +1 more source
npj Digital MedicineWith the growing prevalence of cognitive decline in ageing populations, accessible and scalable screening tools are essential for early intervention. This study investigated the potential of automated speech analysis as a proxy for cognitive assessment ...
Jonathan Heitz +2 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
The thorny issue of pluralism, 'paradigm wars' and politics in qualitative methods and mixed methods research [PDF]
, 2014 MIXED METHODS RESEARCH is clearly a recognized area of research in psychology. With the ascendancy of that work there does need to be a sustained debate surround methods and approaches in psychology.
Bridger, Alexander +1 more
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Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Navigating research: qualitative methods
, 2016 • To outline qualitative research methods using the example of educational research • To demystify and position educational research within an accessible social research framework • To explore and evaluate suitable methodological approaches • To ...
Haynes, L., Laur, C., Thompson, B.
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Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source