Results 121 to 130 of about 66,179,807 (296)

LIBS of Low-Alloyed Lead Systems: Chemometric Data Processing and Quantitative Analysis

open access: yesAnalytica
A probabilistic–deterministic design of experiments (PDDoE) approach was employed to optimize laser-induced breakdown spectroscopy (LIBS) parameters for the quantitative determination of minor components in lead-based alloys.
Vitaliy Fomin   +8 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Manifesto for medical research [PDF]

open access: yes, 2015
The MRCG want to ensure there is a dynamic medical research environment in Ireland. Ensuring priority investment for medical research will help to deliver patient care, public health service transformation and economic and enterprise development.
Medical Research Charities Group
core  

Towards a speech-based digital biomarker for cognitive impairment: speech as a proxy for cognitive assessment

open access: yesnpj Digital Medicine
With the growing prevalence of cognitive decline in ageing populations, accessible and scalable screening tools are essential for early intervention. This study investigated the potential of automated speech analysis as a proxy for cognitive assessment ...
Jonathan Heitz   +2 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Navigating research: qualitative methods

open access: yes, 2016
• To outline qualitative research methods using the example of educational research • To demystify and position educational research within an accessible social research framework • To explore and evaluate suitable methodological approaches • To ...
Haynes, L., Laur, C., Thompson, B.
core  

Research methods in psychology

open access: yes
Fresh, friendly and accessible, this book makes psychology research methods come alive. Calmly steering readers through the research process, it covers all stages – from theory, generating research topics and being an ethical researcher to data ...
Earnshaw, Deborah   +2 more
core   +1 more source

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