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Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Analysis of the Wear of Forming Tools in the Process of Extruding Ceramic Bands Using Selected Research Methods for Evaluating Operational Durability. [PDF]

Materials (Basel)
Hawryluk M, Marzec J, Leśniewski T, Krawczyk J, Madej Ł, Perzyński K.   +5 more
europepmc   +1 more source

Gender scores in epidemiological research: methods, advantages and implications. [PDF]

Lancet Reg Health Eur
Ballering AV, Olde Hartman TC, Rosmalen JGM.   +2 more
europepmc   +1 more source

In Vitro Research Methods Used to Evaluate Shaping Ability of Rotary Endodontic Files-A Literature Review. [PDF]

Dent J (Basel)
Elemam RF, Azul AM, Dias J, El Sahli K, de Toledo Leonardo R.   +4 more
europepmc   +1 more source

Description and Evaluation of a Pharmacy Graduate Health Services Research Methods Course. [PDF]

Pharmacy (Basel)
Axon DR.
europepmc   +1 more source

From warehouse to ward: applying implementation research methods to the device identification, qualification, distribution, and management process within the Newborn Essential Solutions and Technologies (NEST360) alliance. [PDF]

BMC Glob Public Health
Dougherty K, Kirby RP, Claud K, Palamountain KM, Asma E, Alooh M, Kumara D, Gate V, Khalid A, Banda G, Peter HD, Osuagwu C, Richards-Kortum R, Oden ZM, Bohne CA, Hirschhorn LR.   +15 more
europepmc   +1 more source

Essential Foundational Education Research Methods Articles for Graduate Medical Educators: A Delphi Study. [PDF]

J Grad Med Educ
Feig E, Mayersak R, Luo C, Cook MR, Sigman L, Jordan J, Riddell J, Zuo L, Villamagna AH, Bonura E, Yarris LM.   +10 more
europepmc   +1 more source

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Research Methods

The Journal of the American Dental Association, 2016
This chapter presents the methodology of this study and the rationale for using qualitative interviewing as the preferred approach. It discusses the practicalities of the research methodology, including the processes of developing an interview framework, engaging participants and analysing research material using Grounded Theory.
Irene Zempi, Imran Awan
  +7 more sources

Research Methods

2019
Abstract The authors present an overview of methodological issues in comparative studies, which have their intellectual roots in experimental psychology. This is followed by an introduction of the key concepts of bias (unintended sources of score differences, such as differential social desirability) and equivalence (implications of bias
He, Jia, van de Vijver, Fons
openaire   +3 more sources

Mixed methods research

Nursing Standard, 2015
Mixed methods research involves the use of qualitative and quantitative data in a single research project. It represents an alternative methodological approach, combining qualitative and quantitative research approaches, which enables nurse researchers to explore complex phenomena in detail.
Halcomb, Elizabeth J, Hickman, Louise
openaire   +3 more sources