Results 81 to 90 of about 65,959,704 (250)

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Construction of training system for research nurses in multicenter drug clinical trial institutions

Huli yanjiu
ObjectiveTo construct a training system for research nurses in multicenter drug clinical trial institutions.MethodsLiterature retrieval and analysis were conducted to draft the initial training system for research nurses in multicenter drug clinical ...
WANG Jingjing, ZHU Xu, YU Shuyan
doaj  

Research status quo of effort syndrome in clinical nurses

Huli yanjiu, 2005
The occurrence of effort syndrome in nurses is related to their long-time heavy work stress. The numbers of clinical nurses with effort syndrome increased year by year because of the lack of nurses, enlarged working range and relatively lower pay.
段东红, 宋新莲
doaj  

Identifying Nursing Students' Misconceptions Concerning Long‐Term Weight Loss Recommendations: A Phenomenographic Study

Nursing Open
Aim To gain insight into nursing students' learning by exploring misconceptions in their understanding of long‐term dietary recommendations given for weight loss in overweight or obese patients.
Sergio Yuste, Jagoba Zarandona, Susana Cariñanos‐Ayala, Marta Arrue, Leyre Gravina   +4 more
doaj   +1 more source

Development Model Management Education Soft Skill Nurses Hospital Education

Journal of Business and Social Review in Emerging Economies, 2018
This research intent for management model development education soft skill nurse at education hospital, and has influence increase nurse’s soft skill on nurses unit. This model development utilizes method with approaching Research & Development from Borg
Rasdi Ekosiswoyo, Mardliyah Mardliyah, Sugiyo Sugiyo, Titi Prihatin   +3 more
doaj   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

South Korean first-time mothers’ knowledge of digestive health problems in infancy and their utilization of health care facilities for digestive health concerns: a descriptive study [PDF]

Child Health Nursing Research
Purpose This study aimed to assess the knowledge level of first-time mothers regarding digestive health issues in infancy and to examine the utilization of healthcare facilities for such problems. Methods Data from 119 first-time mothers of infants under
Yijin Lee, Kyung-Sook Bang
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source