Results 131 to 140 of about 1,666,160 (306)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Developing an e-infrastructure for social science [PDF]

, 2007
We outline the aims and progress to date of the National Centre for e-Social Science e-Infrastructure project. We examine the challenges faced by the project, namely in ensuring outputs are appropriate to social scientists, managing the transition from
Allan, Rob, Baird, Kenny, Birkin, Mark, Crouchley, Rob, Daw, Michael, de la Flor, Grace, Dutton, William H., Edwards, Pete, Hewitt, T., Jie, Wei, Jirotka, Marina, Lin, Yuwei, Miller, Ken, Procter, Rob, Schroeder, Ralph, Turner, A., Voss, Alex, Yang, Xiaobo   +17 more
core  

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

SELECTING INPUTS AND OUTPUTS IN DATA ENVELOPMENT ANALYSIS BY DESIGNING STATISTICAL EXPERIMENTS(<Special Issue>Operations Research for Performance Evaluation)

, 2009
Hiroshi Morita, Necmi K. Avkiran
openalex   +2 more sources

Covid-19 and Thyroid: A Scopus-based Bibliometric Assessment of Research Output [PDF]

, 2021
Devi Dayal, Brij Mohan Gupta, Madhu Bansal, Pamali Mahasweta Nanda   +3 more
openalex   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Multi-level DEA Approach in Research Evaluation [PDF]

, 2007
It is well known that the discrimination power of DEA models will be diminishing if too many inputs or outputs are used. It is a dilemma if the decision makers want to select comprehensive indicators to present a relatively holistic evaluation using ...
Liu, Wenbin, Meng, Wei, Zhang, Daqun
core  

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

The unprincipled principal: how Romania’s inconsistent research reform impacted scientific output [PDF]

Vasile Cernat
openalex   +1 more source

Improved Probability Prediction Method Research for Photovoltaic Power Output [PDF]

, 2019
Ze Cheng, Qi Liu, Wen Zhang
openalex   +1 more source