Results 141 to 150 of about 1,650,608 (285)

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Research output falls [PDF]

Nature, 2010
openaire   +1 more source

Developing an e-infrastructure for social science [PDF]

, 2007
We outline the aims and progress to date of the National Centre for e-Social Science e-Infrastructure project. We examine the challenges faced by the project, namely in ensuring outputs are appropriate to social scientists, managing the transition from
Allan, Rob, Baird, Kenny, Birkin, Mark, Crouchley, Rob, Daw, Michael, de la Flor, Grace, Dutton, William H., Edwards, Pete, Hewitt, T., Jie, Wei, Jirotka, Marina, Lin, Yuwei, Miller, Ken, Procter, Rob, Schroeder, Ralph, Turner, A., Voss, Alex, Yang, Xiaobo   +17 more
core  

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Favoring Generalists over Specialists: How Attentional Biasing Improves Perceptual Category Learning [PDF]

, 1999
A model of cortical learning is proposed, which incorporates supervised feedback using two forms of attention: (i) feature-specific attention which allows the network to learn associations between specific feature conjunctions (or categories) and outputs,
Williamson, James
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

EU-Africa partnerships in health research from 2014 to 2023: Outputs and lessons learnt

International Journal of Infectious Diseases
Objectives: The European & Developing Countries Clinical Trials Partnership (EDCTP) supports clinical research partnerships between countries in Europe and sub-Saharan Africa.
Debora Bade, Andreia Coelho, Dominika Jajkowicz, Henrique Pinheiro, Thomas Nyirenda, Michael Makanga, Pauline Beattie   +6 more
doaj   +1 more source

Regional convergence in outputs and incomes in Italy and the U.S. [PDF]

One of the key topics of international and inter-regional research in the past decade has been that of convergence or divergence in real outputs and incomes across countries and regions within individual countries.
Khatiwada, Ishwar, Schachter, Gustav, Sum, Andrew   +2 more
core  

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

The Economic Impact of Enhanced Access to Research Findings [PDF]

, 2006
The environment in which research is being conducted and disseminated is undergoing profound change, with new technologies offering new opportunities, changing research practices demanding new capabilities, and increased focus on research performance.
Houghton, John, Sheehan, Peter
core