Results 241 to 250 of about 1,666,160 (306)

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Large language models are homogeneously creative. [PDF]

PNAS Nexus
Wenger E, Kenett YN.
europepmc   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Multifactorial Correlation Analysis of Nursing Unit Staffing Based on Gray Relation Analysis: A Cross-Sectional Study. [PDF]

J Nurs Manag
Pang X, Cao X, Chen Z, Shi J, Pan J, Mao L.   +5 more
europepmc   +1 more source

Enzymatic and microbial routes to bioplastics: The green chemistry frontier of biopolymers

FEBS Open Bio, EarlyView.
Microbial biosynthesis and engineered enzyme platforms are expanding the design space of polyhydroxyalkanoate bioplastics. By combining fermentation, PHA synthase engineering and cell‐free modular systems, tailored biodegradable polymers can be produced with tunable properties, supporting more sustainable materials and future circular bioeconomy ...
Giovanni Gallo, Emma Piccoli, Luca Bombardi, Martina Aulitto, Salvatore Fusco   +4 more
wiley   +1 more source

From Policy to Action: Co-Designing Research With Local Government to Advance Urban Greening. [PDF]

Health Promot J Austr
Williams C, Tefera Y, Soebarto V, Kandulu J, Lowe M, Humphrey J, Croeser T, Daddow L, Willsmore B.   +8 more
europepmc   +1 more source

A cross-country comparison of nursing research outputs in relation to funding: An artificial intelligence-enhanced multivariate analysis

Elena Sblendorio, Marco Tomietto, Vincenzo Dentamaro, Alessio Lo Cascio, Guglielmo Imbrìaco, Michela Piredda, Giancarlo Cicolini   +6 more
openalex   +1 more source

Bibliometric Assessment of European and Sub-Saharan African Research Output on Poverty-Related and Neglected Infectious Diseases from 2003 to 2011

, 2015
J. Gabrielle Breugelmans, Michael Makanga, Ana Lúcia V. Cardoso, Sophie Mathewson, Bethan R. Sheridan-Jones, Karen Gurney, Charles S. Mgone   +6 more
openalex   +2 more sources

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source