Results 61 to 70 of about 25,786 (248)

Rare Disease Research Partnership (RAinDRoP): a collaborative approach to identify research priorities for rare diseases in Ireland [version 2; peer review: 2 approved]

HRB Open Research, 2020
Background: Rare diseases are individually rare, but collectively these conditions are common. Research on rare diseases are currently focused on disease-specific needs rather than a life-course perspective.
Suja Somanadhan, Emma Nicholson, Emma Dorris, Aoife Brinkley, Avril Kennan, Eileen Treacy, Awan Atif, Sean Ennis, Vicky McGrath, Derick Mitchell, Grace O’Sullivan, Julie Power, Anne Lawlor, Paul Harkin, Sally Ann Lynch, Philip Watt, Avril Daly, Susie Donnelly, Thilo Kroll   +18 more
doaj   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Reducing health inequalities in the deaf community: a priority setting exercise

BMC Health Services Research
Background The Deaf community experiences health inequalities including higher mortality rates, increased prevalence of chronic conditions, and poorer access to healthcare services compared to the general population.
Anna Selby, Alison Jones, Helen Radford, Daniel Hind   +3 more
doaj   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Prioritising Research Agenda For E-Commerce In Malaysia

International Business & Economics Research Journal (IBER), 2011
The recent advent of World Wide Web has changed the traditional marketing paradigm in a dramatic way. Under a computer-mediated marketing framework the operations are no longer controlled by boundaries and time constraints. The new paradigm provides firms the whole wired world as potential market to capture.
Ali Khatibi, V. Thyagarajan, Adeline Chua, Mohd Ismail   +3 more
openaire   +2 more sources

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Effectiveness of artificial intelligence for test prioritisation in distributed systems of Ukrainian and international software development

Ìнформаційні технології та компʼютерна інженерія
The growing complexity of distributed Continuous Integration/Continuous Delivery (CI/CD) systems, and the limited scalability and stability of conventional heuristic methods for test prioritisation, necessitates the investigation of alternative methods ...
A. Zadorozhnii
doaj   +1 more source

Prioritise research on vaccines for pregnant and breastfeeding women [PDF]

The Lancet, 2022
Terra, Manca, Françoise, Baylis, Flor M, Munoz, Karina A, Top   +3 more
openaire   +2 more sources

How phagocytic cells kill bacteria: Lessons from a professional killer

FEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source