Results 81 to 90 of about 65,817,525 (246)

Attitudes of cancer patients toward ctDNA‐based liquid biopsy for follow‐up

Molecular Oncology, EarlyView.
This mixed‐methods study explored cancer patients' experiences, knowledge, and preferences regarding ctDNA‐based liquid biopsy for follow‐up. Awareness of ctDNA was low and recall of previous liquid biopsy was imperfect, yet acceptance was high.
Siddharth Chhajlani, Laura Mariën, Caro De Weerdt, Sanne Wouters, Laure‐Anne Teuwen, Hans Prenen, Katleen Janssens, Timon Vandamme   +7 more
wiley   +1 more source

Diagnostic gap analysis in animal health through combining public databases

BMC Veterinary Research
The burden of infectious diseases in animals, particularly in livestock, significantly impacts global food security and economic development. Despite advancements in diagnostic technologies, substantial gaps remain that hinder effective disease control ...
Latifa Elhachimi, Natalia Ciria, Johannes Charlier   +2 more
doaj   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Assessing the cost effectiveness of using prognostic biomarkers with decision models: case study in prioritising patients waiting for coronary artery surgery [PDF]

, 2009
: Objective To determine the effectiveness and cost effectiveness of using information from circulating biomarkers to inform the prioritisation process of patients with stable angina awaiting coronary artery bypass graft surgery.
Hemingway, Harry,, Hemingway, Harry, Sculpher, Mark,, Timmis, Adam,, Sculpher, Mark, Abrams, Keith,, Henriksson, M, K Fitzpatrick, Natalie,, Hingorani, Aroon D,, Chen, R, Kaski, Juan-Carlos,, Stenestrand, Ulf, Stenestrand, Ulf,, Hingorani, AD, Feder, G, Henriksson, Martin,, Janzon, M, Janzon, Magnus, Fitzpatrick, NK, Abrams, K, Damant, Jacqueline, Feder, Gene,, Palmer, S, Damant, Jacqueline,, Shipley, MJ, Chen, Ruoling, Timmis, A, K Fitzpatrick, Natalie, Abrams, Keith, Sculpher, M, Palmer, Stephen, Stenestrand, U, Keogh, B, Janzon, Magnus,, Damant, J, Feder, Gene, Shipley, Martin J, Henriksson, Martin, Kaski, JC, Hingorani, Aroon D, Keogh, Bruce, Keogh, Bruce,, Hemingway, H, Timmis, Adam, Fitzpatrick, Natalie K, Shipley, Martin J,, Kaski, Juan-Carlos   +46 more
core   +1 more source

Scoping review on the prioritisation of high-consequence infectious pathogens for research preparedness and response to health emergencies

BMC Medicine
Background Funding for health research is intrinsically limited; therefore, priority-setting is necessary to optimise investments. Prioritisation is particularly important for epidemic and pandemic pathogens, as preparedness needs for hypothetical ...
Nicolas Pulik, Holly Sadler, Thokozani Nyasulu, Richmonda Pearce, Yazdan Yazdanpanah, Hervé Raoul, Alice Norton   +6 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

A quantitative exploration of flight prioritisation principles, using new delay costs

, 2012
New costs of delay to the airline are presented for a range of aircraft and by phase of flight. It is shown how these costs may be suitable for cost optimisations during flight prioritisation decision-making.
Cook, A.J., Tanner, G.
core   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

A User-Driven Prioritisation Process implementation and optimisation for ATFM hotspot resolution [PDF]

The current and forecast air traffic levels lead to demand-capacity imbalances, which are dealt with by delaying flights through the allocation of air traffic flow management (ATFM) slots.
Pilon, Nadine, Gurtner, Gérald, Gasparin, Andrea, Castelli, Lorenzo, Bolić, Tatjana, Gurtner, G., Bolic, T., Gasparin, A., Castelli, L., Pilon, N.   +9 more
core   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source