Results 61 to 70 of about 10,947,079 (306)

Construction And Research Of Full Balance Energy Of Variational Problem Motion Surface And Groundwater Flows [PDF]

open access: yes, 2017
Based on the laws of conservation of mass and momentum the basic equations of motion with unknown quantities velocity and piezometric pressure are written.
Venherskyi, P. (Petro)
core   +2 more sources

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

Self-Affirmation Improves Problem-Solving under Stress [PDF]

open access: yes, 2013
High levels of acute and chronic stress are known to impair problem-solving and creativity on a broad range of tasks. Despite this evidence, we know little about protective factors for mitigating the deleterious effects of stress on problem-solving ...
A Martens   +42 more
core   +3 more sources

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

Insights into a long life without cancer: The case of the bowhead whale

open access: yesMolecular Oncology, EarlyView.
Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley   +1 more source

Problem-Oriented Researches in Literary Studies [PDF]

open access: yesLiterary Arts, 2012
Being familiar with research methodology causes an increase in the effectivity and efficiency in research. One of the most valuable subjects in research methodology is to discuss about principles and skill of "Problem-oriented" researches that seems to ...
Ahmas Razi
doaj   +3 more sources

Application of SWOT and PESTEL analysis in combating economic crimes and when identifying threats to economic security of the state

open access: yesПроблеми Законності, 2017
The article examines the state of economic crime in Ukraine based on SWOT and PESTEL analysis when determining economic crimes as a threat to the economic security of Ukraine as well as using these analytical methods to identify the ways of combating ...
Вячеслав Анатолійович Некрасов   +1 more
doaj   +1 more source

RESEARCH PROBLEMS OF PHARMACOLOGY. [PDF]

open access: yesJAMA: The Journal of the American Medical Association, 1903
The main object of pharmacology is to supply a basis for rational therapeutics. The entire medical profession has always been in accord as to the desirability of this end, but the methods of pharmacology did not at first secure universal recognition.
openaire   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

PROPUESTA DE UN EJERCICIO CONCEPTUAL EN CINEMATICA COMO PROBLEMA DE INVESTIGACION DIDACTICO [PDF]

open access: yesGondola, 2010
In this article there talks each other the discussion that exists concerning the utility of the exercises of paper and pencil, being this one of the principal weakness in the contemporary school.
SERGIO HIDALGO FRANCO   +1 more
doaj  

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