Results 211 to 220 of about 77,403,001 (321)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

The role of knowledge users in public–private research programs: An evaluation challenge

, 2014
L. Hessels, T. Wardenaar, W. Boon, Matthias Ploeg   +3 more
semanticscholar   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Evolution of natural and social science interactions in global change research programs

Proceedings of the National Academy of Sciences of the United States of America, 2013
H. Mooney, A. Duraiappah, A. Larigauderie   +2 more
semanticscholar   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Understanding the Barriers to Pediatric Oncologist Engagement and Accrual to Clinical Trials in National Cancer Institute-Designated Community Oncology Research Programs. [PDF]

JCO Oncol Pract, 2020
Dickens DS, Roth ME, Pollock BH, Langevin AM.   +3 more
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Feasibility of connecting regional research programs to national multisite trials emanating from the CTSA Trial Innovation Network. [PDF]

J Clin Transl Sci, 2020
Hassell L, Gregor C, Melvin A, Goss C, Coker RH, Laukes C, Albritton S, Brant J, Amoroso P, Whitener N, Tuttle KR.   +10 more
europepmc   +1 more source

Steering with big words: articulating ideographs in research programs

, 2014
Colette Bos, B. Walhout, A. Peine, H. van Lente   +3 more
semanticscholar   +1 more source

SPSS and SAS programs for determining the number of components using parallel analysis and Velicer’s MAP test

Behavoir research methods, instruments & computers, 2000
B. O'Connor
semanticscholar   +1 more source