Results 41 to 50 of about 5,285,257 (310)
PROX1 is a transcriptional regulator of MMP14
Scientific Reports, 2018 The transcription factor PROX1 is essential for development and cell fate specification. Its function in cancer is context-dependent since PROX1 has been shown to play both oncogenic and tumour suppressive roles.
Silvia Gramolelli +15 more
doaj +1 more source
Redox regulation of GRPEL2 nucleotide exchange factor for mitochondrial HSP70 chaperone
Redox Biology, 2018 Mitochondria are central organelles to cellular metabolism. Their function relies largely on nuclear-encoded proteins that must be imported from the cytosol, and thus the protein import pathways are important for the maintenance of mitochondrial ...
Svetlana Konovalova +11 more
doaj +1 more source
MYCN Amplification in RB1‐Inactivated Retinoblastoma: Association With High‐Risk Features
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background MYCN amplification occurs in a subset of retinoblastoma cases, both with and without RB1 inactivation. It has been suggested that retinoblastomas with MYCN amplification represent a distinct entity with more aggressive clinical behavior.
Kyriaki Papaioannou +9 more
wiley +1 more source
THE TECHNOLOGICAL IMPERATIVE OF COOPERATION OF UKRAINE AND RUSSIA
Модернизация, инновация, развитие, 2016 The article studies the state and trends of scientific and technological cooperation between Ukraine and the Russian Federation with the following characteristics of the objective reasons that promote the widening and development of such cooperation, and
L. I. Fedulova
doaj
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
EMBO Molecular Medicine, 2017 DNA polymerase gamma (POLG), the mtDNA replicase, is a common cause of mitochondrial neurodegeneration. Why POLG defects especially cause central nervous system (CNS) diseases is unknown.
Joni Nikkanen +8 more
doaj +1 more source
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Out-of-School Time Policy Commentary #1: Out-of-School Research Meets After-School Policy [PDF]
, 2002 The past five years have seen a ground swell in public attention and public policy aimed at increasing the availability of after-school programs for children and young teens during the "risk" hours when safety, supervision and homework are of top concern.
core
Cinema programs as a source for research on historical film audiences. Berlin 1945–1949 [PDF]
, 2015 In my paper, I analyse programs from cinemas in all four sectors of occupied Berlin from 1945 to 1949. I focus primarily on ads. Looking at cinema programs allows me to conduct research on local audiences by taking into consideration the social ...
Saryusz-Wolska, Magdalena
core +1 more source
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source