Results 61 to 70 of about 5,285,257 (310)
EMBO Molecular Medicine, 2018 Mitochondrial disorders (MDs) are inherited multi‐organ diseases with variable phenotypes. Inclusion body myositis (IBM), a sporadic inflammatory muscle disease, also shows mitochondrial dysfunction.
Jana Buzkova +11 more
doaj +1 more source
SALSA: a regulator of the early steps of complement activation on mucosal surfaces
Frontiers in Immunology, 2016 Complement is present mainly in blood. However, following mechanical damage or inflammation, serous exudates enter the mucosal surfaces. Here the complement proteins interact with other endogenous molecules to keep microbes from entering the parenteral ...
Martin eReichhardt, Seppo eMeri
doaj +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Review Essay: Reporting Large-Scale Qualitative Research: The Ergography
Forum: Qualitative Social Research, 2008 As social science research programmes tend to increase in scale, reporting their results in a coherent manner is growing more difficult. Andrew WEBSTER's edited volume presents a wealth of social science research and is a pleasant read for many reasons ...
Bart Penders, Annemiek Nelis
doaj
Endothelial Pim3 kinase protects the vascular barrier during lung metastasis
Nature CommunicationsEndothelial cells (ECs) form a tissue-specific barrier for disseminating cancer cells in distant organs. However, the molecular regulation of the ECs in the metastatic niche remains unclear.
Niina M. Santio +9 more
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Summer Research Programs Spark Students\u27 Biomedical Interests [PDF]
, 2005 No abstract ...
Chepenik, Kenneth P., Glick, Jerold A.
core +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Tracing back primed resistance in cancer via sister cells
Nature CommunicationsExploring non-genetic evolution of cell states during cancer treatments has become attainable by recent advances in lineage-tracing methods. However, transcriptional changes that drive cells into resistant fates may be subtle, necessitating high ...
Jun Dai +19 more
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Stem Cell Reports, 2015 CRISPR/Cas9 protein fused to transactivation domains can be used to control gene expression in human cells. In this study, we demonstrate that a dCas9 fusion with repeats of VP16 activator domains can efficiently activate human genes involved in ...
Diego Balboa +5 more
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NASA supported research programs [PDF]
A summary of the scientific NASA grants and achievements accomplished by the University of California, Los Angles, is presented. The development of planetary and space sciences as a major curriculum of the University, and statistical data on graduate ...
Libby, W. F.
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