Results 181 to 190 of about 9,546,528 (270)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Reviewability and supportability: New complementary principles to empower research software practices. [PDF]

Comput Struct Biotechnol J
Zhang H, Maillo A, Khan SA, Martínez-de-Morentin X, Lehmann R, Gomez-Cabrero D, Tegnér J.   +6 more
europepmc   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

DataDesc: A framework for creating and sharing technical metadata for research software interfaces. [PDF]

Patterns (N Y)
Kuckertz P, Göpfert J, Karras O, Neuroth D, Schönau J, Pueblas R, Ferenz S, Engel F, Pflugradt N, Weinand JM, Nieße A, Auer S, Stolten D.   +12 more
europepmc   +1 more source

SlicerDMRI: Diffusion MRI and Tractography Research Software for Brain Cancer Surgery Planning and Visualization. [PDF]

JCO Clin Cancer Inform, 2020
Zhang F, Noh T, Juvekar P, Frisken SF, Rigolo L, Norton I, Kapur T, Pujol S, Wells W, Yarmarkovich A, Kindlmann G, Wassermann D, San Jose Estepar R, Rathi Y, Kikinis R, Johnson HJ, Westin CF, Pieper S, Golby AJ, O'Donnell LJ.   +19 more
europepmc   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

The Power of Social Cognition [PDF]

Journal of Social Structure, 2017
Geoffrey P. Morgan, Kenneth Joseph, Kathleen M. Carley   +2 more
doaj   +1 more source

Best practices to evaluate the impact of biomedical research software-metric collection beyond citations. [PDF]

Bioinformatics
Afiaz A, Ivanov AA, Chamberlin J, Hanauer D, Savonen CL, Goldman MJ, Morgan M, Reich M, Getka A, Holmes A, Pati S, Knight D, Boutros PC, Bakas S, Caporaso JG, Del Fiol G, Hochheiser H, Haas B, Schloss PD, Eddy JA, Albrecht J, Fedorov A, Waldron L, Hoffman AM, Bradshaw RL, Leek JT, Wright C.   +26 more
europepmc   +1 more source

An environment for sustainable research software in Germany and beyond: current state, open challenges, and call for action. [PDF]

F1000Res, 2020
Anzt H, Bach F, Druskat S, Löffler F, Loewe A, Renard BY, Seemann G, Struck A, Achhammer E, Aggarwal P, Appel F, Bader M, Brusch L, Busse C, Chourdakis G, Dabrowski PW, Ebert P, Flemisch B, Friedl S, Fritzsch B, Funk MD, Gast V, Goth F, Grad JN, Hegewald J, Hermann S, Hohmann F, Janosch S, Kutra D, Linxweiler J, Muth T, Peters-Kottig W, Rack F, Raters FHC, Rave S, Reina G, Reißig M, Ropinski T, Schaarschmidt J, Seibold H, Thiele JP, Uekermann B, Unger S, Weeber R.   +43 more
europepmc   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source