Results 71 to 80 of about 9,546,528 (270)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

Worse Than Spam: Issues In Sampling Software Developers

, 2017
Background: Reaching out to professional software developers is a crucial part of empirical software engineering research. One important method to investigate the state of practice is survey research.
Fisher D., Markham A., United States Department of Health, Education and Welfare.   +2 more
core   +1 more source

Research Software Engineering

, 2022
Vorstellung des Schwerpunktbereichs Research Software Engineering (RSE) im Rahmen des eScience-Tags am 28.03.2022.
openaire   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Mind the Gap: Bridging the Sustainable Software Systems Research Divide [PDF]

, 2015
Sustainability is a major concern to humanity as a result of the consequences of the rapid consumption of the planets finite natural resources, combined with exponential economic and population growth.
Becker, Christoph, Betz, Stefanie, Chitchyan, Ruzanna, Duboc, Leticia, Easterbrook, Steve, Penzenstadler, Birgit, Rodriguez-Navas, Guillermo, Seyff, Norbert, Venters, Colin   +8 more
core  

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Aplicação e análise de processo de desenvolvimento de software: um estudo de caso no GPES-IFPB

Revista Principia, 2018
The Software Engineering Research Group from the Federal Institute of Paraiba is developing a research to identify and publicize on the web the best practices in software development processes, seeking to propagate their use among professionals and ...
Samyra Lara Ferreira Almeida, Nadja da Nóbrega Rodrigues, Heremita Brasileiro Lira, Carlos Diego Quirino Lima, Ana Karina de Melo Pedrosa Dunning, Rayssa Mª S. de Freitas   +5 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Research bibliography: dynamic geometry software

, 2002
This bibliography lists research that has investigated the use of dynamic geometry software (DGS) in the teaching and learning of mathematics. The bibliography is not intended to be exhaustive; rather it includes the major studies across the range of ...
Jones, Keith
core