Results 141 to 150 of about 62,404,405 (312)
Status of Toxicological Research in India [PDF]
Chemical Research in Toxicology, 2008 openaire +2 more sources
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Analysis of the Status and Impacts of NCTR Projects [PDF]
BDK85 977-30NCTR 77934/BDK85 977-30U.S.DOT DTRS98-G-0032The National Center for Transit Research (NCTR) at the University of South Florida (USF) assessed the implementation status and identified the outcomes and impacts of the results of 30 Florida ...
University of South Florida. Center for Urban Transportation Research +2 more
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FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Irish Health Research Forum meeting: theme: how can legislation facilitate health research? Report [PDF]
, 2016 This report presents the proceedings of the Irish Health Research Forum on May 10th, 2016 on how legislation can facilitate health research. The implementation of the EU regulations on Clinical Trials (EUCT) and Data Protection (EUDP) in 2016, and the ...
Medical Research Charities Group
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Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Medical Research Charities Group: Annual report 2016
, 2017 2016. Our role is to be the champion of medical research charities, enabling them to maximise their impact in all areas of health research and to highlight their incredibly important role in society.
Medical Research Charities Group
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Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Health research in action 2019
, 2019 Actions and outcomes enabled by HRB-funded ...
Health Research Board
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