Results 141 to 150 of about 6,302,219 (264)

High Elevation Research In Pakistan: The MART/AZR Project Annual Report 1989

This report summarizes the status of research at AZRI at the initiation of the project. Research achievements during the life of the project and recommendations during the future direction of research for each of the groups at AZRI.
Research Institute, Arid Zone
core  

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Research status and hotspots of the systemic immune-inflammation index: A bibliometric analysis. [PDF]

Medicine (Baltimore)
Yu M, Bai Y, Guo X, Wang H.
europepmc   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Research status and trends of pharmaceutical care in hospitals from an international perspective (1990-2024): A bibliometric analysis. [PDF]

Medicine (Baltimore)
Zhang S, Wu C, Liang L, Yan J.
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Global research status in the treatment of glaucoma: a systematic bibliometric analysis. [PDF]

Int J Ophthalmol
Liu WH, Shu C, Jia BD, Li XR.
europepmc   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

The Determinants of Labour Force Status among Indigenous Australians [PDF]

It is well established that Indigenous Australians are heavily over-represented among Australia’s most disadvantaged citizens. An important component of this disadvantage is the limited and often unsuccessful engagement of Indigenous people with the ...
Benjamin J. Stephens
core  

Tropical fruits in the Mediterranean Basin: current research status, priorities, and knowledge gaps. A systematic review. [PDF]

Front Plant Sci
Massaad M, Scuderi D, Andolina F, Bellitti S, Buscaglia A, Gugliuzza G, La Sala G, Mezzano M, Salsi G, Tinebra I, Farina V.   +10 more
europepmc   +1 more source