Results 101 to 110 of about 2,262,807 (264)
Adolescência, autonomia e pesquisa em seres humanos
Revista BioéticaEste artigo tece considerações sobre o tema da adolescência como uma fase única na vida, na qual a autonomia ganha cada vez mais força. O objetivo do estudo é discutir as implicações éticas da pesquisa epidemiológica, clínica ou farmacológica com os ...
Maria Teresa Aquino de Campos Velho +2 more
doaj
Frontiers in MedicineBackgroundPediatricians play a pivotal role in clinical research, and their research competence is essential for advancing hospital-based studies and fostering the development of pediatric disciplines.
Bingya Zheng +3 more
doaj +1 more source
Matching Older Research Subjects to Disease Demographics: First You Need to Know the Demographics. [PDF]
J Am Geriatr Soc, 2020 Zauflik M, Eckstrom E.
europepmc +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Patron-Driven Subject Access: How Librarians Can Mitigate That “Power to Name”
In the Library with the Lead Pipe, 2017 In Brief Information organization and access is one of the core goals of librarianship. However, as librarians, we have the power to control what language patrons must use when searching for items.
Jessica L. Colbert
doaj
Do patients and research subjects have a right to receive their genomic raw data? An ethical and legal analysis. [PDF]
BMC Med Ethics, 2020 Schickhardt C, Fleischer H, Winkler EC.
europepmc +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source