Results 191 to 200 of about 2,262,807 (264)

Exploring the Effects of Attribute Framing and Popularity Cueing on Hearing Aid Purchase Likelihood. [PDF]

Audiol Res
St Jean CR, Cummine J, Singh G, Hodgetts WB.   +3 more
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Social evaluation of skilfulness in Tonkean macaques (Macaca tonkeana) and brown capuchins (Sapajus apella). [PDF]

Anim Cogn
Hirel M, Marziliano M, Meunier H, Rakoczy H, Fischer J, Keupp S.   +5 more
europepmc   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

SARS-CoV-2 Infection Associated with HHV-6A Reactivation and an Inhibitory KIR2DL2/HLA-C1 Immunogenetic Profile. [PDF]

Microorganisms
Rizzo S, Ferraresi M, Strazzabosco G, Baroni M, Sanz JM, Passaro A, Bortolotti D, Rizzo R, Schiuma G.   +8 more
europepmc   +1 more source

Expectation as a Risk for Covid-19-Related Olfactory Changes: Observations From the California Farmworkers Health Survey. [PDF]

Risk Anal
Ridgway D, Sandhu NK, Mora AM, Kogut K, Brown P, Eskenazi B.   +5 more
europepmc   +1 more source

First-in-Human Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ASP1617, a Cathepsin-S Inhibitor, in Healthy Adult Subjects. [PDF]

Clin Transl Sci
Kojima T, Chen W, Smulders R, Stanhope S, Kowalski D, Heo N, Moy S, Goldston A, Han D, Zhu T.   +9 more
europepmc   +1 more source

Research: Human Subjects

, 2015
openaire   +1 more source

Physiological foundation modeling for subclinical disease assessment: a prospective pilot. [PDF]

JAMIA Open
Yuan W, Xu S, Dionisi S, von Herrmann K, Frederick-Dyer K, Cheung-Flynn J, Kennedy C, Flynn CR, Lipnick S.   +8 more
europepmc   +1 more source