Results 81 to 90 of about 61,346,701 (255)

What to Do When Everyone Wants You to Collaborate: Managing the Demand for Library Support in Systematic Review Searching

Journal of the Canadian Health Libraries Association, 2015
The demand for systematic review support in academic health sciences libraries is increasing. To manage the demand, the John W. Scott Health Sciences Library at the University of Alberta has created an action plan consisting of eight strategies.
Sandy Campbell, Marlene Dorgan
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Pilot wrap-around support initiative: Enhanced support for internally funded CTSA pilot awards

Journal of Clinical and Translational Science
The Penn State Clinical and Translational Science Institute (CTSI) Pilot Wrap-Around Support Initiative, implemented in the 2023 pilot funding cycle, was designed to help research teams access comprehensive research support for their pilot projects ...
Kelsey C. Stoltzfus, Tyler J. Deal, John P. Vanden Heuvel, Aron E. Lukacher, Susan Simkins, Nikolay V. Dokholyan, Jennifer L. Kraschnewski   +6 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Avaliação de estratégias de gestão de ciência e tecnologia: um estudo de caso

Revista de Saúde Pública
A partir de implementação de um modelo de gestão de ciência e tecnologia em institutos de pesquisa do Estado de São Paulo, Brasil, foi estudada a capacidade desse sistema para geração de informações gerenciais e avaliado o incentivo à produção científica
Júlio Cesar Rodrigues Pereira, Sueli Gonsalez Saes   +1 more
doaj  

ENHANCING THE ROLE OF LIBRARIES IN COMPREHENSIVE UNIVERSITY DEVELOPMENT: AN EVALUATION FROM RANKING CRITERIA

Tạp chí Khoa học
This study focuses on exploring and analyzing the key roles of the library for a university through university ranking index, an important determinant of the success and reputation of higher education institutions globally.
Nguyen Phuc Quan
doaj   +1 more source

The Ph.D.-candidate as an information literate resource: developing research support and information literacy skills in an informal setting

Liber Quarterly: The Journal of European Research Libraries, 2013
This article aims at suggesting a new way of developing research support for PhD-candidates. Previous research on the field of research support greatly focuses on the librarians’ competencies and how to assist researchers with what they lack in ...
Hilde Daland
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source