Results 171 to 180 of about 901,210 (313)

Exploring working relationships between midwifery support workers and midwives in a community setting [PDF]

open access: yes
This qualitative study explores the working roles and relationships that exist between midwifery support workers (MSWs) and midwives in a community setting.
Ellis, Deborah
core  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

A Decision Support System (DSS) for Project Management in the Bio-diesel Industry [PDF]

open access: yes
The European biodiesel industry is currently facing several challenges affecting the profitability of investment projects in the industry. Among these challenges are higher prices for oilseeds, which are the main input for biodiesel production, lower ...
Alin Paul OLTEANU
core  

Design of a topic-centered research-based teacher guide as support for teachers’ planning and teaching, and professional learning

open access: yes
This thesis presents a design research project, comprising five papers on the design and implementation of a topic-centered research-based teacher guide for quadratic equations in Swedish upper-secondary school. The thesis aims to explore if and how such teacher guides can be designed to support mathematics teachers in their planning and teaching, and ...
openaire   +2 more sources

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

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